Solvent-free and catalyst-free direct alkylation of alkenes

Li, Meng-Yao; Li, Jiatong; Gu, Ao; Nong, Xiao-Mei; Zhai, Shuyang; Yue, Zhu-Ying; Feng, Chen-Guo; Liu, Yingbin; Lin, Guo-Qiang

doi:10.1039/d3gc02685j

Cited by 6 publications

(3 citation statements)

References 51 publications

(24 reference statements)

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“…In recent years, the field of aggregology has garnered significant attention owing to its emphasis on investigating the physicochemical properties exhibited by molecular aggregates. 110 , 111 The AIE effect 112 is ascribed to the confinement of RIM, which restricts molecular rotation and vibration. 113 However, recent investigations have proposed that the restriction of access to the dark state (RADS) also constitutes a crucial factor in elucidating the AIE mechanism.…”

Section: Applications Of 13-diene-based Aiegensmentioning

confidence: 99%

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Nong,

Gu,

Zhai

et al. 2024

iScience

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Section: Applications Of 13-diene-based Aiegensmentioning

confidence: 99%

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Nong,

Gu,

Zhai

et al. 2024

iScience

Self Cite

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“…These objectives can be met by inhibiting some receptors that are involved in both upstream and downstream insulin signaling pathways, including Dipeptidyl peptidase‐4 (DPP‐4), sodium glucose co‐transporter (SGLT), free fatty acid receptor 1 (FFAR1), G protein‐coupled receptor (GPCR), protein tyrosine phosphatase 1 B (PTP1B) peroxisome proliferator‐activated receptor (PPAR), aldose reduction (PEPCK), Alpha‐amylase and Alpha‐glucosidase [5] . Heterocyclic compounds, particularly those containing nitrogen and Sulfur atoms, have drawn a lot of interest in medicinal chemistry because of their diverse pharmacological qualities [6] . The incorporation of these heteroatoms into the molecular framework imparts unique electronic and steric characteristics, enabling specific interactions with target proteins and enzymes involved in diabetes pathogenesis [7] .…”

Section: Introductionmentioning

confidence: 99%

Recent Studies of Nitrogen and Sulfur Containing Heterocyclic Analogues as Novel Antidiabetic Agents: A Review

Gharge,

Alegaon

2024

Chemistry & Biodiversity

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The prevalence of diabetes mellitus is on the rise, which demands for the identification of novel antidiabetic drugs. There is a need for safer and more effective alternatives because the therapy methods now available to manage diabetes have limits. Due to their diverse pharmacological characteristics, heterocyclic molecules with nitrogen and Sulfur atoms have become intriguing candidates in medicinal chemistry. These substances have a wide variety of structures that can be customized to target different pathways associated with diabetes and can affect important biological targets involved in glucose homeostasis. This review provides a thorough summary of the most recent studies on heterocyclic analogues of nitrogen and Sulfur as prospective antidiabetic agents. This review examines the variety of their structural forms, their methods of action, and assesses the results of preclinical and clinical investigations on their effectiveness and safety. Additionally, further optimization and development of innovative antidiabetic medications are highlighted, as well as the difficulties and prospects for the future in utilizing the therapeutic potential of these analogues. This study seeks to stimulate additional investigation and cooperation between researchers and medicinal chemists, promoting improvements in the creation of efficient and secure antidiabetic medicines to fulfil the needs in the management of diabetes.

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“…Furthermore, when reactions are conducted under solvent-free conditions, solvation phenomena will not need to be considered, which may provide an opportunity for chemists to realize the reactions that could not be achieved in conventional solvents before. Therefore, developing novel reactions without requiring the usage of solvents and catalysts is an important subject in green chemistry [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Solvent- and Catalyst-Free Synthesis of gem-Difluorinated and Polyfluoroarylated Compounds with Nucleophilic or Electrophilic Fluorine-Containing Reaction Partners, Respectively

Li,

2024

Molecules

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A novel, efficient and environmentally friendly solvent-free and catalyst-free approach for the synthesis of structurally diverse gem-difluorinated and polyfluoroarylated derivatives with readily available nucleophilic and electrophilic fluorine-containing reaction partners, difluoroenoxysilane and pentafluorobenzaldehyde, is described. This neat protocol is induced by the direct hydrogen-bond interactions between fluorinated and non-fluorinated reactants without the use of heavy metal catalysts or volatile organic solvents and with no need for column chromatographic separation for most cases.

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Solvent-free and catalyst-free direct alkylation of alkenes

Abstract: A convenient method for synthesizing aryl-containing trisubstituted alkenes through direct alkylation of alkenes was successfully achieved under solvent-free and catalyst-free conditions. The absence of solvents was found to be crucial...

Cited by 6 publications

References 51 publications

1,3-diene-based AIEgens: Stereoselective synthesis and applications

1,3-diene-based AIEgens: Stereoselective synthesis and applications

Recent Studies of Nitrogen and Sulfur Containing Heterocyclic Analogues as Novel Antidiabetic Agents: A Review

Solvent- and Catalyst-Free Synthesis of gem-Difluorinated and Polyfluoroarylated Compounds with Nucleophilic or Electrophilic Fluorine-Containing Reaction Partners, Respectively

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