Solvent-Free N-Formylation: An Experimental Application of Basic Concepts and Techniques of Organic Chemistry

Abstract

N-Formamides are important intermediates in the synthesis of many pharmacologically active compounds and are used as protecting groups for amines or as catalysts in different reactions. The current Nformylation experiment is designed as a part of an introductory organic chemistry course for undergraduate students. The experiment includes formylation of substituted aromatic amines using formic acid under solventfree conditions. Students are introduced to laboratory safety precautions, reaction mechanism, and basic laboratory techniques such as a solvent-free reaction setup, reflux, filtration, melting point determination, yield calculation, and lab report write-up. Students synthesized four different formamides in 50−80% yield as a straightforward application of nucleophilic substitution reactions.

Implication of Mini Project Organic Chemistry Experiments for Improving Organic Chemistry Concept

“…Bagi mahasiswa calon guru kimia, kemampuan dalam praktikum kimia organik tidak lepas dari penguasaan akan konsep kimia organik baik sebelum kegiatan, pelaksanaan maupun setelah diperoleh temuan dari praktikum yang telah dilakukan (Omar et al, 2020). Begitu pula sebaliknya, jika penguasaan konsep kimia organik tidak begitu dikuasai, maka praktikum tidak akan terlaksana dengan baik, terlebih lagi untuk pendidikan lebih lanjut maupun saat menjadi guru…”

Fatty Acid Conjugated Chalcones as Tubulin Polymerization Inhibitors: Design, Synthesis, QSAR, and Apoptotic and Antiproliferative Activity

“…Chalcones may be isolated from various plants as secondary metabolites and intermediates in flavonoid biosynthesis and have demonstrated a wide variety of biological and therapeutic activities . Their core structure consists of two aromatic rings connected with a propenone spacer that can be easily synthesized with various modifications of their aromatic rings. , Early chalcone research was focused on incorporation of multiple methoxy and hydroxy group substitutions at either or both aromatic rings to mimic colchicine and natural CA-4, which led to a wide variety of antitumor chalcones inhibiting tubulin polymerization . Excessive methoxy and hydroxy group substitution of chalcones reduces their antitumor effect and thus has led to research efforts in which the two aromatic rings are replaced with different heterocycles.…”