Solvent-free one-pot reactions for annulating a pyrimidine ring on thiazoles under microwave irradiation

Yadav, Lal Dhar S.; Dubey, Suman; Yadav, Beerendra S.

doi:10.1016/s0040-4020(03)00854-8

Cited by 21 publications

(7 citation statements)

References 17 publications

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“…Yadav et al [ 41 ] reported a one‐pot annulation strategy to construct 5,7‐dihydro‐5H‐thiazolo[3,2‐a]pyrimidin‐5‐one derivatives using microwave power without solvent. A model reaction was performed by reacting glycine 111 , acetic anhydride 112, and thiazole Schiff base 113 in microwave energy.…”

Section: Synthetic Strategiesmentioning

confidence: 99%

Microwave‐assisted diversified synthesis of pyrimidines: An overview

Kumar

2021

Journal of Heterocyclic Chem

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Pyrimidines and their hybrid molecules have continued to be a favorable area for organic chemists owing to their richness in natural and synthetic compounds with multifarious involvement in pharmaceuticals and polymers and act as ligands. Different novel and greener synthetic protocols were developed in the last decades, but microwave‐assisted synthetic protocols played a significant role in constructing pyrimidine and its derivatives. In this article, we summarized the microwave‐supported strategy for the construction of pyrimidine fused or linked/tethered with other heterocycles, polysubstituted pyrimidines, solid‐supported synthesis of pyrimidines, and ionic liquid‐catalyzed strategies for the synthesis of pyrimidine and its derivatives reported in the last decade. Solid‐supported protocols using resins and ionic liquid‐catalyzed strategies afforded the corresponding products with excellent yield by dual activation. In most of the reports, the microwave‐irradiated approach was compared with conventional/traditional heating and found better in terms of reaction time, yield, atom economy, adherence with green chemistry principles, and reduction in purification wastage. Various authors evaluated the in vitro potential of synthesized pyrimidine derivatives for antimicrobial and antimalarial potential, and found moderate to excellent biological activity.

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Section: Synthetic Strategiesmentioning

confidence: 99%

Microwave‐assisted diversified synthesis of pyrimidines: An overview

Kumar

2021

Journal of Heterocyclic Chem

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“…Recently, we have found that some pyrimidone and pyrimidinedione derivatives have emerged in the field of chemotherapy and have promising biological and anticancer properties .…”

Section: Introductionmentioning

confidence: 99%

Efficient and Easy One‐Pot Synthesis of New 3,5‐Dioxo‐thiazolo[2,3‐a] pyrimidine‐6‐carbonitrile and 4,6‐Dioxo‐pyrimido[2,1‐b][1,3]thiazine‐7‐carbonitrile Derivatives

Serrar

Boukhris

Hassikou

et al. 2014

Journal of Heterocyclic Chem

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“…The pyrimidine nucleus occurs in biologically important products such as nucleic acids, vitamins, coenzymes and pharmacologically useful products of plant origin. With the intention to synthesize more potent antimicrobial agents, the pyrimidine moiety has been condensed with different types of heterocycles such as furan 7 , thiophene 8 , pyrrole 9 , pyrazole [10][11] , thiazole 12 , imidazole [13][14] , pyrazine 15 and indole 16 etc. Further to our search for new antimicrobial agents we report herein the preparation of new isoxazoline, pyrimidine and pyrazoline chalcone derivatives from 4-acetylphenyl-3-chloro-1-benzothiophene-2-carboxamide compound.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activities of Benzothiophene Derivatives

Aganagowda

Thamyongkit

Petsom

2012

J. Chil. Chem. Soc.

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ABSTRACT3-Chlorobenzothiophene-2-carbonyl chloride 1 was reacted with 4-aminoacetophenone in acetone to give compound 2. In order to prepare chalcones 3a-d, compound 2 was condensed with various aldehydes in the presence of KOH in DMF. These chalcones 3a-d on cyclization with urea, thiourea, hydroxylamine hydrochloride, phenyl hydrazines and hydrazine hydrate gave the corresponding oxapyrimidines 4a-d, isoxazolines 5a-d, pyrazoles 6a-h, pyrazolines 7a-d and thiopyrimidines 8a-d, respectively. The structures of all the synthesized compounds were confirmed by spectral data and had been screened for antibacterial activity.

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Solvent-free one-pot reactions for annulating a pyrimidine ring on thiazoles under microwave irradiation

Cited by 21 publications

References 17 publications

Microwave‐assisted diversified synthesis of pyrimidines: An overview

Microwave‐assisted diversified synthesis of pyrimidines: An overview

Efficient and Easy One‐Pot Synthesis of New 3,5‐Dioxo‐thiazolo[2,3‐a] pyrimidine‐6‐carbonitrile and 4,6‐Dioxo‐pyrimido[2,1‐b][1,3]thiazine‐7‐carbonitrile Derivatives

Synthesis and Antimicrobial Activities of Benzothiophene Derivatives

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