Solvent-Free One-Pot Synthesis of 2-Thioxodihydro-1<i>H</i>-Imidazole-4,5-Dione using a Multi-Component Reaction of Oxalyl Chloride

A simple, mild and efficient protocol for the synthesis of thioxoimidazolidine-4,5-diones (1-15) from substituted thiourea employing Triton-B/CS2 system has been discussed. The protocol described is an easy, efficient, nature-friendly method using cheap, easily available, less toxic reagents at room temperature. The synthesis involves the reaction between substituted thiourea in toluene and oxalyl chloride at room temperature using phase transfer catalyst Triton-B/CS2 system.

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Solvent-Free One-Pot Synthesis of 2-Thioxodihydro-1H-Imidazole-4,5-Dione using a Multi-Component Reaction of Oxalyl Chloride

Abstract: A series of 2-thioxodihydro-1H-imidazole-4,5-dione derivatives are synthesised via a one-pot multicomponent reaction of primary amines, aryl isothiocyanates and oxalyl chloride under solvent-free conditions at 70 °C in good yields.

Cited by 2 publications

References 17 publications

ChemInform Abstract: Solvent‐Free One‐Pot Synthesis of 2‐Thioxodihydro‐1H‐imidazole‐4,5‐dione Using a Multi‐Component Reaction of Oxalyl Chloride.

ChemInform Abstract: Solvent‐Free One‐Pot Synthesis of 2‐Thioxodihydro‐1H‐imidazole‐4,5‐dione Using a Multi‐Component Reaction of Oxalyl Chloride.

Triton-B Mediated Efficient Synthesis of Thioxoimidazolidine-4,5-diones

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