Solvent ototoxicity in the rat and guinea pig

Lataye, R; Campo, Pierre; Pouyatos, Benoı̂t; Cossec, Benoît; Blachère, V.; Morel, G.

doi:10.1016/s0892-0362(02)00326-4

Cited by 68 publications

(36 citation statements)

References 26 publications

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“…Andere Studien mit großen Kohorten zeigen, dass bis 172 mg/m³ keine ototoxischen Effekte auftreten [56,81,82]. Die Ototoxizität von Toluol wird durch tierexperimentelle Daten unterstützt [83,84].…”

Section: Ototoxizitätunclassified

Richtwerte für Toluol und gesundheitliche Bewertung von C7-C8-Alkylbenzolen in der Innenraumluft

2016

Bundesgesundheitsbl

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Section: Ototoxizitätunclassified

Richtwerte für Toluol und gesundheitliche Bewertung von C7-C8-Alkylbenzolen in der Innenraumluft

2016

Bundesgesundheitsbl

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“…Styrene exposure can cause permanent and progressive damage to the auditory system in rats even after exposure has ceased. 10,11 Styrene has been shown to be a potent ototoxicant by itself, and can have a synergistic effect when presented together with noise or ethanol. 12,13,14,15 …”

Section: Exposure Hazards Of Styrenementioning

confidence: 99%

In-depth study: an occupational exposure assessment of styrene and noise in the fiber-reinforced plastic boat manufacturing industry at Island Packet Yachts (IPY) Largo, Florida.

2007

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A one-week in-depth survey was performed to assess the occupational exposures of styrene vapors, and to evaluate the effectiveness of the engineering controls currently installed for reducing styrene exposures during two distinct fiberglass reinforced plastic (FRP) boat manufacturing processes. The primary objective of this study was to quantify the exposures occurring during both an open and closed mold process. A secondary objective was to asses the noise levels occurring during jobs which involve the use of styrene-based products. The effectiveness of the styrene controls examined in this study was evaluated by measuring styrene concentrations in personal breathing-zone and general-area samples during typical work shifts. The personal breathing-zone samples for the workers in the closed-mold area resulted in a geometric mean styrene concentration of 7.04 to 7.34 parts per million (ppm). The personal-breathing zone samples of workers in the open-molding process ranged from a geometric mean styrene concentration of 11.6 ppm for the small parts laminators and approximately 13 ppm for the hull laminator, large part laminator, and the gelcoater. The general-area air sample results were below 10 ppm for all of the areas sampled.

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“…Since these early studies, the ability of chemicals to directly disrupt auditory function has been established for trichloroethylene (Crofton et al 1993;Fechter et al 1998), toluene (Campo et al 1999;Crofton et al 1994;Johnson 1993), ethyl benzene (Cappaert et al 2001), and styrene , among other agents. In addition, Lataye et al (2001Lataye et al ( , 2003 have nicely identified the route by which solvents enter the cochlea and the pattern of damage that they produce in the inner ear.…”

Section: Ototoxicitymentioning

confidence: 99%

Urinary Creatinine: Barr et al. Respond

Barr¹,

Caudill²,

Jones³

et al. 2005

Environ Health Perspect

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Urinary creatinine is almost universally employed to adjust concentrations of urinary analytes for variations in hydration status. In the February 2005 issue of EHP, Barr et al. used data from the Third National Health and Nutrition Examination Survey (NHANES III) to establish reference ranges for urinary creatinine for specific age and demographic categories (Barr et al. 2005). They reported that the significant predictors of urinary creatinine concentrations include age, sex, race/ethnicity, body mass index, and fat-free mass. Although these indicators have been known for many years, the unintentional adjustment for these covariates when urinary metabolites are expressed per gram creatinine can have profound effects on the interpretation of data. The fact that these effects are often underappreciated or even unnoticed renders this paper highly relevant to exposure assessment and well worth revisiting. In our studies of arsenic methylation and one-carbon metabolism, we have noted several additional complications when expressing urinary arsenic as micrograms per gram creatinine. Note that one-carbon metabolism refers to the folatedependent biochemical pathway responsible for methylation of DNA, arsenic, and hundreds of other substrates.Our study in Bangladesh on 1,650 adults revealed that urinary creatinine concentrations are significantly correlated with plasma folate concentrations-particularly among males, who had a higher prevalence of folate deficiency than females in Bangladesh (Gamble et al. 2005). Although this association had not been previously reported, it is not surprising considering that the formation of creatine from methylation of guanidinoacetate accounts for approximately 75% of all folate-dependent transmethylation reactions (Mudd and Poole 1975) and that creatine is the direct precursor of creatinine.In some analyses, adjusting urinary arsenic for creatinine obscured correlations between folate and arsenic metabolism. In other analyses, correlations between folate and arsenic/creatinine were due in part to the associations between folate and creatinine. Correct interpretation of the data would not be possible without considering the impact of the correlation between urinary creatinine and plasma folate. As did Barr et al. (2005), we decided to include urinary creatinine in the statistical models as a separate independent variable. However, because of the intimate link between creatine metabolism and one-carbon metabolism, inclusion of urinary creatinine in some models resulted in overcontrolling for the effects of folate and homocysteine, our variables of interest. Thus, expression of total urinary arsenic per gram creatinine runs the risk of confounding relationships between total urinary arsenic and arsenic metabolism. Adjusting for the specific gravity of urine was not useful because it is so highly correlated with urinary creatinine.In summary, we concur with Barr et al. (2005) that urinary creatinine should be included in multiple regression models as a separate independent variable; in...

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Solvent ototoxicity in the rat and guinea pig

Cited by 68 publications

References 26 publications

Richtwerte für Toluol und gesundheitliche Bewertung von C7-C8-Alkylbenzolen in der Innenraumluft

Richtwerte für Toluol und gesundheitliche Bewertung von C7-C8-Alkylbenzolen in der Innenraumluft

In-depth study: an occupational exposure assessment of styrene and noise in the fiber-reinforced plastic boat manufacturing industry at Island Packet Yachts (IPY) Largo, Florida.

Urinary Creatinine: Barr et al. Respond

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