Solvent sniffing death

Alha, A; Korte, T.; Tenhu, M

doi:10.1007/bf02114888

Cited by 10 publications

(1 citation statement)

References 8 publications

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“…Again, toluene-related deaths due to respiratory failure, cardiac arrhythmia, and cardiac arrest, which occur at repetitive doses, have been reported in the literature as 'glue sni ng death. (3,4) Xylene-related health problems are especially prominent in environmental and occupational exposure.…”

Section: Discussionmentioning

confidence: 99%

Determination of Toluene and Xylene Levels in Postmortem Tissues of Rats as a Human Autopsy Process

Oflaz,

Butun,

Kuloglu

et al. 2023

Preprint

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Background Toluene and xylene are frequently used aromatic hydrocarbons in industry. It is also a subject of abuse by inhalation since they have lipid solubility and may affect the blood-brain barrier easily. Toluene or xylene exposure has been reported to cause death. Analyzing the levels of Toluene and xylene in toxicological samples obtained during the autopsy process is important for determining the cause of death. It is also known that the levels of toxic substances show differences during the postmortem period. To make a differential diagnosis of toluene or xylene exposure-related deaths, it is necessary to consider the changes in the levels of these two substances in tissues during the postmortem period. This study aimed to examine the changes in toluene or xylene levels in toxicological samples obtained from rats exposed to lethal doses of Toluene or xylene in the postmortem period. Methods; In our study, intraperitoneal administration of toluene, xylene, and corn oil for the control group was administered to the female Wistar Albino rats. All three groups of rats were also classified according to their postmortem sampling after 0, 2, 4, and 6 hours. Each group (Toluene, Xylene, Control) had 16 samples in the pool chart. Toluene and xylene levels in all tissue specimens were investigated by Head Space-Gas Chromatography-Mass Spectrometry. Statistical analysis of the data were performed by using IBM SPSS Statistics 21 windows based statistical package program. Results Xylene was detected at the maximum level at hour zero in liver, adipose and brain tissues. Toluene was measured at its highest level at hour zero in liver, followed by brain, adipose and blood tissues. Conclusion The changes among tissue levels of these two substances in the postmortem period showed different patterns. This Head Space-Gas Chromatography-Mass Spectrometry method validated for tissue procedures, is highly valuable for determining the amounts of toluene and xylene in tissues

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Section: Discussionmentioning

confidence: 99%

Determination of Toluene and Xylene Levels in Postmortem Tissues of Rats as a Human Autopsy Process

Oflaz,

Butun,

Kuloglu

et al. 2023

Preprint

View full text Add to dashboard Cite

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Trichlor�thylen-, Tetrachlorkohlenstoff- und Benzinintoxikation als �tiologischer Faktor bei der Entstehung der Arterio- bzw. Koronarsklerose

Sorgo

1976

Arch Toxicol

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On the occasion of autopsies of 4 toxicomaniac adolescents sniffing and occasionally drinking trichlorethylene, carbon tetrachloride and gasoline severe arteriosclerotic damage of the coronary vessels was encountered. Experimental intoxication of 12 rabbits with these solvents over a period of 10 weeks, each time until a prenarcotic stage, provoked pathological changes in accordance with well known findings but no arteriosclerosis. Ergometrical examination with simultaneous recording of the E.C.G. of 6 adolescents with solvent-sniffing history and of 1 man, working for years under trichlorethylene exposure conditions and showing symptoms of chronic intoxication, revealed no signs of coronary-artery insufficiency. These findings are not inconsistent with the assumption -- though not substantiating it -- of a causal relationship between the intoxication with trichlorethylene, carbon terachloride and gasoline and the development of arteriosclerosis, as the coronary sclerosis may be of the elstic type with a very high degree of adaptability and the probands proved unable to reach the limit of maximum stress. In addition to the main purpose the occurrence of epileptic seizures following chronic trichlorethylene sniffing in one case and the manifestation of pulmonary obstruction following i.v. application of Methyl-Phenidat (Ritalin) in two cases are reported.

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