This article is devoted to the generalization of the Drazin pre-order and the G-Drazin partial order to Core-Nilpotent endomorphisms over arbitrary k-vector spaces, namely, infinite dimensional ones. The main properties of this orders are described, such as their respective characterizations and the relations between these orders and other existing ones, generalizing the existing theory for finite matrices. In order to do so, G-Drazin inverses are also studied in this framework. Also, it includes a generalization of the space pre-order to linear operators over arbitrary k-vector spaces.