2013
DOI: 10.1371/journal.pone.0053437
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Solving Hard Computational Problems Efficiently: Asymptotic Parametric Complexity 3-Coloring Algorithm

Abstract: Many practical problems in almost all scientific and technological disciplines have been classified as computationally hard (NP-hard or even NP-complete). In life sciences, combinatorial optimization problems frequently arise in molecular biology, e.g., genome sequencing; global alignment of multiple genomes; identifying siblings or discovery of dysregulated pathways. In almost all of these problems, there is the need for proving a hypothesis about certain property of an object that can be present if and only … Show more

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Cited by 5 publications
(3 citation statements)
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“…Intensively complex, multidimensional events such as whole somatic aging are likely to be coordinated by a series of differential protein hierarchies, in which lower-dimensionality protein functions, e.g., simple mitogen-activated protein kinase (MAPK) cascades are orchestrated and connected to other linear pathways by master-controlling “keystone” or “hub” proteins ( 13 ). Experimental research into the potential molecular interactions that regulate aging across an organisms life span quickly engenders signaling complexity issues comparable to the mathematical difficulties of optimally solving NP-hard (Non-deterministic Polynomial-time hard) or NP-complete calculations ( 112 , 113 ). Therefore, a more pragmatic approach to the investigation of hyper complex signaling architectures, both for mechanistic knowledge and for eventual therapeutic manipulation of highly complex systems, is to identify the central coordinators of these complex systems.…”
Section: Discussionmentioning
confidence: 99%
“…Intensively complex, multidimensional events such as whole somatic aging are likely to be coordinated by a series of differential protein hierarchies, in which lower-dimensionality protein functions, e.g., simple mitogen-activated protein kinase (MAPK) cascades are orchestrated and connected to other linear pathways by master-controlling “keystone” or “hub” proteins ( 13 ). Experimental research into the potential molecular interactions that regulate aging across an organisms life span quickly engenders signaling complexity issues comparable to the mathematical difficulties of optimally solving NP-hard (Non-deterministic Polynomial-time hard) or NP-complete calculations ( 112 , 113 ). Therefore, a more pragmatic approach to the investigation of hyper complex signaling architectures, both for mechanistic knowledge and for eventual therapeutic manipulation of highly complex systems, is to identify the central coordinators of these complex systems.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, because of continuous advances in MS and proteomics methods, the size of the generated data will continue to increase in the foreseeable future . As a result, the field of proteomics has encountered computational requirements that far exceed the specifications of most common desktop computers . Indeed, for any computational process, the overall speed is determined by the size and amount of the input data, the amount of compute cores that can simultaneously perform calculations, and the availability of the necessary storage capacity.…”
Section: Introductionmentioning
confidence: 99%
“…Indeed it suffices to identify each cell of the considered network to a node of the graph and each non null component of the compatibility matrix to an edge of the graph. The computational complexity of graph coloring is known to be NP-hard [4]. The minimum number of colors for coloring a graph is its chromatic number.…”
Section: Related Workmentioning
confidence: 99%