In this paper, the fuzzy approximate solutions for the fuzzy Hybrid differential equation emphasizing the type of generalized Hukuhara differentiability of the solutions are obtained by using the two-dimensional Müntz–Legendre wavelet method. To do this, the fuzzy Hybrid differential equation is transformed into a system of linear algebraic equations in a matrix form. Thus, by solving this system, the unknown coefficients are obtained. The convergence of the proposed method is established in detail. Numerical results reveal that the two-dimensional Müntz–Legendre wavelet is very effective and convenient for solving the fuzzy Hybrid differential equation.