Abstract. The paper presents mathematical modelling of flow boiling heat transfer in a rectangular minichannel asymmetrically heated by a thin and one-sided enhanced foil. Both surfaces are available for observations due to the openings covered with glass sheets. Thus, changes in the colour of the plain foil surface can be registered and then processed. Plain side of the heating foil is covered with a base coat and liquid crystal paint. Observation of the opposite, enhanced surface of the minichannel allows for identification of the gasliquid two-phase flow patterns and vapour quality. A two-dimensional mathematical model of heat transfer in three subsequent layers (sheet glass, heating foil, liquid) was proposed. Heat transfer in all these layers was described with the respective equations: Laplace equation, Poisson equation and energy equation, subject to boundary conditions corresponding to the observed physical process. The solutions (temperature distributions) in all three layers were obtained by Trefftz method. Additionally, the temperature of the boiling liquid was obtained by homotopy perturbation method (HPM) combined with Trefftz method. The heat transfer coefficient, derived from Robin boundary condition, was estimated in both approaches. In comparison, the results by both methods show very good agreement especially when restricted to the thermal sublayer.