Solving the Clogging Problem: Precipitate‐Forming Reactions in Flow

Poe, Sarah L.; Cummings, Meredith A.; Haaf, Michael; McQuade, D. Tyler

doi:10.1002/ange.200503925

Cited by 34 publications

(30 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Organic reactions have been performed in microfluidic plugs and slugs to exploit the advantages of miniaturization as well as facile heat and mass transfer. Examples of single‐step reactions that have been performed within plugs include the nitration of benzene,184–186 the extraction of acid from kerosene,187 the fluorination of aromatics,49 the bromination of alkenes,188 and precipitate‐forming reactions 189. Monomeric and novolak azo dyes were formed within plugs in a two‐step reaction 47.…”

Section: Applications Of Droplet‐based Microfluidicsmentioning

confidence: 99%

Reactions in Droplets in Microfluidic Channels

2006

View full text Add to dashboard Cite

Fundamental and applied research in chemistry and biology benefits from opportunities provided by droplet-based microfluidic systems. These systems enable the miniaturization of reactions by compartmentalizing reactions in droplets of femoliter to microliter volumes. Compartmentalization in droplets provides rapid mixing of reagents, control of the timing of reactions on timescales from milliseconds to months, control of interfacial properties, and the ability to synthesize and transport solid reagents and products. Droplet-based microfluidics can help to enhance and accelerate chemical and biochemical screening, protein crystallization, enzymatic kinetics, and assays. Moreover, the control provided by droplets in microfluidic devices can lead to new scientific methods and insights.

show abstract

Section: Applications Of Droplet‐based Microfluidicsmentioning

confidence: 99%

Reactions in Droplets in Microfluidic Channels

2006

View full text Add to dashboard Cite

show abstract

“…This feature was first demonstrated in the synthesis of indigo and for imine and amide formation reactions. The precipitate remained in the dispersed phase, whereas the continuous phase preferentially wet the channel walls, preventing the solid product from clogging the channels 178…”

Section: Small‐molecule Synthesis In Dropletsmentioning

confidence: 99%

Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology

et al. 2010

View full text Add to dashboard Cite

Microdroplets in microfluidics offer a great number of opportunities in chemical and biological research. They provide a compartment in which species or reactions can be isolated, they are monodisperse and therefore suitable for quantitative studies, they offer the possibility to work with extremely small volumes, single cells, or single molecules, and are suitable for high‐throughput experiments. The aim of this Review is to show the importance of these features in enabling new experiments in biology and chemistry. The recent advances in device fabrication are highlighted as are the remaining technological challenges. Examples are presented to show how compartmentalization, monodispersity, single‐molecule sensitivity, and high throughput have been exploited in experiments that would have been extremely difficult outside the microfluidics platform.

show abstract

“…Organische Synthesen wurden in der Mikrofluidik sowohl in Oval‐ als auch in Zylinderkompartimenten ausgeführt, wobei die Vorteile der Miniaturisierung und eines einfachen Wärme‐ und Massetransfers im Vordergrund standen. Beispiele für einstufige Reaktionen in Ovalkompartimenten sind die Nitrierung von Benzol,184–186 die Extraktion von Säure aus Kerosin,187 die Fluorierung von Aromaten,49 die Bromierung von Alkenen188 und Fällungsreaktionen 189. In einer zweistufigen Reaktion wurden Monomer‐ und Novolak‐Azofarbstoffe in Ovalkompartimenten synthetisiert 47.…”

Section: Anwendungen Von Mikrofluidiktröpfchenunclassified

Reaktionen in Mikrofluidiktröpfchen

2006

View full text Add to dashboard Cite

Tröpfchenbasierte Mikrofluidiksysteme bieten in der Chemie und Biologie ausgezeichnete experimentelle Möglichkeiten für die Grundlagenforschung und angewandte Forschung. Sie ermöglichen die Miniaturisierung von Reaktionen, indem Reaktionsvolumina in femto‐ bis mikrolitergroßen Tröpfchen kompartimentiert werden. Die Kompartimentierung in Tröpfchen ermöglicht die schnelle Durchmischung der Reagentien, die zeitliche Steuerung der Reaktionen im Bereich von Millisekunden bis zu Monaten, die Steuerung von Grenzflächeneigenschaften und die Synthese und den Transport von festen Reagentien und Produkten. Mithilfe von tröpfchenbasierten Mikrofluidiksystemen können Anwendungen im Bereich des chemischen und biologischen Screenings, der Proteinkristallisation und der Enzymkinetik verbessert und beschleunigt werden. Darüber hinaus bietet die mögliche Steuerung von Tröpfchen in Mikrofluidikeinheiten Aussichten auf neue wissenschaftliche Methoden und Erkenntnisse.

show abstract

Solving the Clogging Problem: Precipitate‐Forming Reactions in Flow

Cited by 34 publications

References 23 publications

Reactions in Droplets in Microfluidic Channels

Reactions in Droplets in Microfluidic Channels

Microdroplets in Microfluidics: An Evolving Platform for Discoveries in Chemistry and Biology

Reaktionen in Mikrofluidiktröpfchen

Contact Info

Product

Resources

About