Solving the conundrum of Job: a probable biblical description of chronic renal failure with neurological symptoms

Resende, Luiz Antônio de Lima; Kirchner, Daniel Rocco; Resende, Lucilene Silva Ruiz e

doi:10.1590/s0004-282x2009000300037

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…It is important to rule out systemic causes of neurological symptoms in COVID-19 patients, such as hepatic, renal failure, hypercapnia/hypoxic encephalopathies, coinfections, and treatment-related adverse effects, by blood gas analysis (ABG), liver and renal function tests, blood ammonia, evoked potential (EP), quantitative spectral electroencephalography (EEG) analysis, cerebrospinal fluid (CSF) test, magnetic resonance imaging (MRI), medication and treatment history, etc. (57)(58)(59)(60). Previous studies have found some red flags to suspect COVID-19 presence in patients with headache, such as fever, cough, systemic symptoms, prior medical history, some neurologic symptoms, and increased C-reactive protein (61).…”

Section: Auxiliary Tests For Nervous System Infections In Covid-19mentioning

confidence: 99%

Differential Diagnosis and Hospital Emergency Management for Fastlane Treatment of Central Nervous System Infection Under the COVID-19 Epidemic in Changsha, China

Yang

Chi²,

Chen

et al. 2020

Front. Neurol.

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Importance: Corona virus disease 2019 (COVID-19) has long latent period, strong infectivity, and non-specific symptoms and signs in the upper respiratory tract. Some initial neurological symptoms appear, including dizziness, headache, seizures, slurred speech, disturbance of consciousness, and limb paralysis among a few COVID-19 patients, which share similar manifestations with central nervous system (CNS) infection. Improving the diagnostic efficiency of suspected CNS infection patients on the basis of preventing and controlling COVID-19 plays a key role in preventing nosocomial and cross infections. This study intends to formulate a hospital emergency management system of fastlane treatment of CNS infection for epidemic prevention and control, aiming at providing references and guidelines for the government and medical institutions to improve the efficiency of treating CNS infection patients in the clinical practice during COVID-19.Observations: This study formulated a framework of a fastlane treatment of CNS infection based on the cooperation of resources and experience, aiming at the key and difficult problems faced by the hospital emergency management system during the COVID-19 outbreak in Changsha, China. The main problem of formulating the hospital emergency management system is efficiently identifying whether CNS infection was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The framework improves the efficiency of diagnosing and treating CNS infections by standardizing the diagnosis and treatment process of patients in emergency observation and strengthening the management of inpatient wards, aiming at assisting medical staff during clinical practice. Conclusions and Relevance:The hospital emergency management system of a fastlane treatment of CNS infection for epidemic prevention and control of the COVID-19 outbreak is a professional and multisystem project, which needs the cooperation of various resources and the experience of clinical leadership.

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Section: Auxiliary Tests For Nervous System Infections In Covid-19mentioning

confidence: 99%

Differential Diagnosis and Hospital Emergency Management for Fastlane Treatment of Central Nervous System Infection Under the COVID-19 Epidemic in Changsha, China

Yang

Chi²,

Chen

et al. 2020

Front. Neurol.

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“…The adult onset of Job’s symptoms (as opposed to infancy, which also would have been fatal prior to intravenous immune globulin and antibiotics), and the lack of any noted family history of this dominant disorder makes this congenital disease a highly unlikely cause (the tragic death of his children, again after infancy, is due to attacking groups and to a mysterious “wind”). Scholars in the medical literature have proposed everything from kidney disease, 16 to primary dermatologic disorders, 17 , 18 to poisoning, 19 to psychiatric disorders, 20 , 21 and have taken to psychoanalyzing Job as well. 22 – 25 Nonetheless, it is valuable to ponder ancient encounters with disease and affliction, and contrast them to the modern ways that we understand, perceive, and deal with genetic diseases.…”

Section: Stat3lof Ad-hies As a Paradigm For Altering The Balance Of Pmentioning

confidence: 99%

Learning from Job: A Rare Genetic Disease and Lessons of Biblical Proportions

Milner

2018

Rambam Maimonides Med J

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Dominant negative mutations in STAT3, a critical signaling molecule and transcription factor in multiple organ systems, lead to a rare monogenic disease called the STAT3 loss-of-function, autosomal dominant hyper-IgE syndrome (STAT3LOF AD-HIES). The original name for this syndrome, Job’s syndrome, was derived from the observation that patients had a propensity to develop skin boils, reminiscent of the affliction cast upon the biblical Job. Many fascinating observations have been made regarding the pathogenesis of the disease and the role STAT3 plays in human health and disease. Additionally, quite a few phenotypic descriptions from the Book of Job are similar to those seen in patients with STAT3LOF AD-HIES, beyond just the boils. This complex multisystem genetic disorder is a challenge clinically and scientifically, but it also brings into question how we approach genetic syndromes beyond just the technical aspects of research and treatment.

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The affliction of job, as painted by Jusepe de Ribera: A dermatological observation going back to the 17th century

Lefrère,

Kluger

2024

Acad Dermatol Venereol

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Solving the conundrum of Job: a probable biblical description of chronic renal failure with neurological symptoms

Cited by 4 publications

References 11 publications

Differential Diagnosis and Hospital Emergency Management for Fastlane Treatment of Central Nervous System Infection Under the COVID-19 Epidemic in Changsha, China

Differential Diagnosis and Hospital Emergency Management for Fastlane Treatment of Central Nervous System Infection Under the COVID-19 Epidemic in Changsha, China

Learning from Job: A Rare Genetic Disease and Lessons of Biblical Proportions

The affliction of job, as painted by Jusepe de Ribera: A dermatological observation going back to the 17th century

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