Somatic stem cells for regenerative dentistry

Abstract

Complex human tissues harbour stem cells and/or precursor cells, which are responsible for tissue development or repair. Recently, dental tissues such as periodontal ligament (PDL), dental papilla or dental follicle have been identified as easily accessible sources of undifferentiated cells. The dental stem cell biology might provide meaningful insights into the development of dental tissues and cellular differentiation processes. Dental stem cells could also be feasible tools for dental tissue engineering. Constructing complex structures like a periodontium, which provides the functional connection between a tooth or an implant and the surrounding jaw, could effectively improve modern dentistry. Dental precursor cells are attractive for novel approaches to treat diseases like periodontitis, dental caries or to improve dental pulp healing and the regeneration of craniofacial bone and teeth. These cells are easily accessible and, in contrast to bone-marrow-derived mesenchymal stem cells, are more closely related to dental tissues. This review gives a short overview of stem cells of dental origin.

The Role of Lysyl Oxidase-like 2 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells

“…Colonies of hDPSCs were selected after evaluating the levels of the MSC-specific cell surface markers, CD44, CD73, and CD105, by FACS analysis. We used a hematopoietic surface molecule, CD34, as a negative control (Morsczeck et al, 2008). The isolated clones that tested positive for CD44, CD73, and CD105 and negative for CD34 were used for subsequent experiments (Fig.…”

Whole-organ engineering with natural extracellular materials

“…While the multipotency of adult stem cells is being realized as an autologous source for various tissues, limitations remain for re-engineering immature tissue [129]. For instance, since enamel forming tissues have undergone apoptosis prior to tooth eruption, it is necessary to identify a dental epithelial cell source for bioengineered enamel production.…”

Dental Kök Hücre Kaynaklari Ve Kemi̇k Doku Rejenerasyonunda Kullanilma Potansi̇yelleri̇

“…59 Kraniofasiyal ve alveoler kemik rejenerasyonunda dental kaynaklı kök hücreler yeni yaklaşım olarak görülmektedir. 41 Miura ve arkadaşları 38 süt dişi pulpasından elde edilen kök hücrelerin yeni kemik oluşturduğunu bildirmişlerdir.…”

“…Postnatal kök hücrelerin esas görevleri defektli yada hasara uğramış dokuyu tamir etmek ve dokunun devamlılığını sağlamaktır. 34,35 Embriyonik ve postnatal kök hücreler arasındaki farkın sebebi, bu hücrelerin özelleştiği hücrelere dönüşümünün farklılık göstermesidir. 36 …”