Somatic symptoms, sleep disturbance and psychological distress among women undergoing oocyte pick‐up and <i>in vitro</i> fertilisation–embryo transfer

Lin, Ya-Hui; Chueh, Ke‐Hsin; Lin, Jia-Ling

doi:10.1111/jocn.13194

Cited by 27 publications

(26 citation statements)

References 21 publications

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“…Factors exacerbated by sleep deprivation [19,38,80,130], including excessive sympathetic activation [1,4,104], oxidative stress [31,49], and increased ghrelin [66] may be detrimental to IVF outcomes. Additionally, psychological distress, which could be mediated by poor sleep [70], may reduce IVF success [56] or result in discontinuation of the IVF process [43]. Therefore, sleep remains an under-investigated, modifiable target that may provide a non-pharmacological, cost-effective, and patient-centered avenue to improve IVF outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Sleep disturbances are thought to be common in women undergoing infertility treatment [36] despite minimal data to support this hypothesis [69,70,84]. In one investigation evaluating a heterogeneous group of women in infertility clinic, 34 % answered yes to the question Bdo you experience disturbed sleep^ [84].…”

Section: Sleep Disturbances In Women Undergoing Infertility Treatmentmentioning

confidence: 99%

“…When the same group evaluated the PSQI in 100 patients undergoing IVF, 23 % had poor quality sleep during oocyte retrieval and 46 % had poor quality sleep during embryo transfer [70]. Poor quality sleep was an independent predictor of psychological distress during the IVF procedure [70].…”

Section: Sleep Disturbances In Women Undergoing Infertility Treatmentmentioning

confidence: 99%

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Sleep, Circadian Rhythms, and Fertility

Goldstein

Smith

2016

Curr Sleep Medicine Rep

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Adequate sleep is crucial for general health and wellbeing. Although the neuronal control of the reproductive axis and sleep-generating neurons share an anatomical location, little is known regarding the impact of sleep and circadian disruption on fertility in women. Animal models have established clear circadian control of the pre-ovulatory luteinizing hormone surge. Additionally, disruption of the circadian timing system by exposure to abnormal light-dark cycles or mutations of core clock genes results in diminished reproductive capacity in animals. Abnormalities in menstruation, fertility, and early pregnancy maintenance in female shift workers provide evidence for a role of circadian rhythms in the reproductive health of women. Reproductive hormones may modify sleep, and the relationship is bidirectional such that sleep disruption may alter the profile of reproductive hormone secretion. Therefore, sleep, apart from its circadian timing, may also have relevance in attaining pregnancy. Additionally, infertility is associated with psychological distress which may result in poor quality sleep. The interaction between psychological distress and disturbed sleep in reproduction has garnered minimal attention and may be a crucial factor to consider during the evaluation and treatment of infertility. This work reviews animal models and evidence in women that suggest a role for sleep and circadian rhythms in reproductive health and reveals areas that require future investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Sleep Disturbances In Women Undergoing Infertility Treatmentmentioning

confidence: 99%

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Sleep, Circadian Rhythms, and Fertility

Goldstein

Smith

2016

Curr Sleep Medicine Rep

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“…6 The same study team assessed the PSQI in women undergoing IVF and found that 23% of women had poor sleep during oocyte retrieval and 46% had poor sleep at the time of embryo transfer. 7 …”

Section: Introductionmentioning

confidence: 99%

“…17 Not surprisingly, women with disturbed sleep (as measured by the PSQI) were 2-3 times more likely to display psychological distress during the IVF process. 7 Despite the vulnerability of this group to stress and resultant sleep disruption, the impact of poor quality sleep on reproductive outcomes during IVF, in conjunction with or independently from psychological stress, remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Sleep in women undergoing in vitro fertilization: a pilot study

et al. 2017

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Objective Sleep disturbances are thought to be frequent in women undergoing IVF despite minimal research of this hypothesis. Our goal was to longitudinally assess sleep duration and disturbances in women undergoing IVF and assess impact of habitual sleep duration on oocytes retrieved, an important outcome in IVF. Methods Actigraphy and questionnaire batteries containing sleep and psychometric instruments were performed prior to and throughout 24 IVF cycles. Results TST <7 hours was present in 46%, 57%, 69%, and 42% of baseline, stimulation, post-oocyte retrieval, and post-embryo transfer recordings. ESS>10 was noted in 24%, 33%, and 36% of cycles during baseline, stimulation, and post-embryo transfer. PSQI>5 was noted in 57%, 43%, and 29% of cycles during baseline, stimulation, and post-embryo transfer. TST (F=2.95, p=0.04) and ESS (F=4.36, p=0.02) were the only sleep metrics in which a significant main effect of time was found by mixed models analysis. The final linear regression model chosen by stepwise selection to best explain the variability in oocytes retrieved included anti-mullerian hormone, day 3 follicle stimulating hormone, and baseline TST and explained 40% of the variance in oocytes retrieved (adjusted R2=0.40, p=0.03). Although not statistically significant, a trend towards a linear association between baseline TST and oocytes retrieved was seen with an increase of oocytes retrieved by 1.5 for every hour increase in TST (p=.09). Conclusions This is the first study to describe, with subjective and objective measures, sleep disturbances present throughout the IVF cycle. Importantly, a trend towards a linear relationship between TST and oocytes retrieved was found in this pilot study. Sleep may be a modifiable target to improve outcomes in women undergoing IVF and further investigations are needed.

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