2004
DOI: 10.1016/s0193-953x(03)00116-3
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Somatic treatment of bipolar disorder in children and adolescents

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Cited by 8 publications
(6 citation statements)
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“…The early course of bipolar disorder in adolescents is often chronic and refractory to treatment, while the long‐term prognosis appears similar to that of adults (422–424, 449). Although available data are limited, and have methodological issues, the results of both RCTs and open clinical trials suggest that adolescent‐onset bipolar disorder will likely respond to the same agents as adult‐onset bipolar disorder (450). Like adult bipolar disorder, childhood‐onset bipolar disorder has a chronic course with a high rate of recurrence and evidence suggests that prophylactic therapy is needed (451, 452).…”
mentioning
confidence: 99%
“…The early course of bipolar disorder in adolescents is often chronic and refractory to treatment, while the long‐term prognosis appears similar to that of adults (422–424, 449). Although available data are limited, and have methodological issues, the results of both RCTs and open clinical trials suggest that adolescent‐onset bipolar disorder will likely respond to the same agents as adult‐onset bipolar disorder (450). Like adult bipolar disorder, childhood‐onset bipolar disorder has a chronic course with a high rate of recurrence and evidence suggests that prophylactic therapy is needed (451, 452).…”
mentioning
confidence: 99%
“…Broadly‐defined bipolar symptoms in early‐onset patients, especially those co‐occurring with attention or conduct problems and mixed states, are highly resistant to monotherapy with a mood‐stabilizer (14). Lithium is an effective treatment of adolescent bipolar disorder with comorbid substance dependence but combined pharmacotherapies of mood‐stabilizing medications (carbamazepine or divalproate and lithium) (15) and stimulants or a novel antipsychotic medication (risperidone and olanzapine) lead to significant improvement in a broader range of symptoms (14, 16), without inducing mania or exacerbating mood symptoms (7).…”
Section: Treatmentmentioning
confidence: 99%
“…Lithium has been effective in many studies with adults and a variety of case studies, and one placebo-controlled study with adolescents has shown that it can be effective with children (Emslie & Mayes, 2001). However, a smaller percentage of prepubertal children respond well to lithium than do adolescents or adults, with most reports showing that about 50% to 60% of children respond well to lithium (Weller, Danielyan, & Weller, 2002). The lack of response by a sizeable percentage of children is similar to the lack of response by the small percentage of adults who have the rapid cycling of symptoms that are common in children with bipolar disorder (Emslie & Mayes, 2001).…”
Section: Pharmacotherapymentioning
confidence: 99%
“…Most children and adolescents who take lithium experience side effects (AACAP, 1997a). Common side effects include nausea, diarrhea, enuresis, tremors, fatigue, and sedation (Weller et al, 2002). Lithium has a significant effect on heart functioning in a small percentage of children.…”
Section: Pharmacotherapymentioning
confidence: 99%