Somatomedin and Growth after Renal Transplantation

Saenger, Paul; Wiedemann, Eckehart; Schwartz, Ernest; Korth-Schütz, Sigrun; Lewy, John E.; Riggio, Robert R.; Rubin, Albert L.; Stenzel, Kurt H.; New, Maria I.

doi:10.1203/00006450-197403000-00003

Cited by 106 publications

(22 citation statements)

References 22 publications

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“…Anabolic steroids may also be beneficial [124]. After renal transplantation only half of the children will grow at a normal rate, even when somatomedin levels return to normal [246]. Growth retardation following transplantation is directly correlated with the dose of prednisone.…”

mentioning

confidence: 98%

Stunted growth with more or less normal appearance

et al. 1982

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mentioning

confidence: 98%

Stunted growth with more or less normal appearance

et al. 1982

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“…There have been several reports concerning changes in bioactivity and the serum concentration of SMsin uremic patients. Studies employing bioassays have shown low levels of SMactivity in patients with chronic renal failure (10)(11)(12). Lowserum levels of SMby radioimmunoassay (RIA) using serum extracted with acid-ethanol, which recovered SMs and excluded SM-binding proteins, were also reported in adult patients undergoing chronic hemodialysis (13).…”

Section: Discussionmentioning

confidence: 99%

47 XXY/46 XY Mosaic Klinefelter's Syndrome Presenting with Multiple Endocrine Abnormalities.

et al. 1996

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Wereport here a rare case of 47 XXY/46 XYmosaic Klinefelter's syndromeassociated with multiple endocrine disorders. A 35-year-old male admitted for the evaluation of renal dysfunction and recurrent bone fractures was diagnosed as having Klinefelter's syndrome by endocrinological examinations and sex chromosomeanalysis. He has suffered from diabetes mellitus for morethan ten years. The serum FSHand LH levels were high together with low free testosterone and estradiol levels. There was a discrepancy between basal serum GHand somatomedin-C levels. On admission, thyroid function revealed thyrotoxicosis with low radioactive iodine uptake and negative thyroid autoantibodies. During hospitalization, serum FT3 and FT4 levels were gradually decreased and serum TSHlevels became elevated, leading to the diagnosis of subacute thyroiditis. Serum ACTH levels showed high basal levels with delayed, exaggerated responses to insulin-induced hypoglycemia. Rapid ACTHtest (1 24ACTH0.25 mg) showed low cortisol responses and many of the adrenocortical steroids in plasma and urine were low or low normal. Furthermore, bone mineral density (BMD) by DEXAshowed marked osteoporosis. Possible mechanisms underlying these varied endocrine disorders remain to be elucidated. (Internal Medicine 35: 396-402, 1996)

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“…Children with uremia associated with growth failure have reduced IGF-I bioactivi ty, as assessed by bioassay [ 19,20], Dialysis or renal transplantation increases growth veloci ty in close correlation with increases in plas ma IGF-I bioactivity [20], The reduced IGF-I bioactivity appears to be a consequence of an increase in IGFBPs. Children with end-stage renal failure or chronic renal failure have greatly increased IGFBP 1 and IGFBP3 con centrations and an excess of IGFBP capacity [21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fetal Nephrectomy on Insulin-Like Growth Factors and Their Binding Proteins in Sheep

Iwamoto¹,

McConnell²

1997

Neonatology

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Bilateral nephrectomy retards fetal growth and decreases somatomedin (insulin-like growth factor-I, IGF-I) activity. To determine whether nephrectomy alters the synthesis of IGF-I or its binding proteins (IGFBPs), we studied 6 sets of twin fetuses. Kidneys were removed bilaterally from 1 twin of each set at 112–122 days of gestation (term 145 days). Plasma IGF-I concentrations were greater in nephrectomized fetuses than in the intact twins during the 1st week (261 ± 35 vs. 153 ± 21 ng/ml, p < 0.02; mean ± SE) but not the 2nd week after surgery. Nephrectomy increased the abundance of the IGFBPs to levels 2–3 times greater than those in intact twins. Fetal hepatic IGFBP1 mRNA levels increased in 4 of 6 nephrectomized fetuses, while those of IGF-I, IGF-II, IGFBP2 were unchanged. Nephrectomy markedly alters the abundance of IGF-I and IGFBPs in plasma probably through mechanisms unrelated to synthesis.

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Somatomedin and Growth after Renal Transplantation

Cited by 106 publications

References 22 publications

Stunted growth with more or less normal appearance

Stunted growth with more or less normal appearance

47 XXY/46 XY Mosaic Klinefelter's Syndrome Presenting with Multiple Endocrine Abnormalities.

Effect of Fetal Nephrectomy on Insulin-Like Growth Factors and Their Binding Proteins in Sheep

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