Somatomedin C (insulin‐like growth factor 1) in adults with Down's syndrome

Abstract

ABSTRACT. In a Norwegian institution for the mentally retarded, 29 adults with chromosomally verified Down's syndrome were compared to other mentally retarded patients with respect to serum somatomedin C (SmC) (insulin‐like growth factor 1 [IGF‐1]). Contrary to what has been observed in children, no shortage of SmC could be demonstrated in the adults with Down's syndrome. The results were within the normal range, and there was no difference between those with Down's syndrome and the other mentally retarded patients. Human growth hormone (HGH) and body height were studied in a previous work. Some correlations with these data are, nevertheless, included herein because they are of relevance. SmC correlated with body height in Down's syndrome, while there was no correlation between SmC and HGH or between HGH and body height.

Normal growth hormone secretion in overweight young adults with Down syndrome

“…For instance, both increased and decreased concentrations of IGF-I have been reported in overweight individuals [27,28]. In the present study there was no association between IGF-I and body composition in the DS subjects despite the fact that BMI was increased and IGF-I levels lay in the lower part of the reference interval, findings in agreement with prior studies [3,29].…”

“…The fact that in previous studies exogenous GH improved both growth [41] and psychomotor development [41,42] in children with DS would appear to support a functional GHD in DS. In addition, Hestnes et al [29] have suggested that maturation of IGF-I may be delayed in DS, with low levels during childhood, resulting in impaired growth. However, further studies are required to determine whether the effect of GH is altered in DS, leading to a functional GHD despite an apparently normal GH profile.…”

Does the Insulin‐Like Growth Factor System Interact with Prostaglandins and Proinflammatory Cytokines During Neurodegeneration?

“…Individuals with Down syndrome (DS) overexpress APP, typically develop AD pathology during their third to fourth decade, and have impaired GH‐IGF function (99–104). Considering the relationship among IGF, insulin, and diabetes with AD pathology, it is interesting to find that individuals with DS are at greater risk of developing diabetes (105–107).…”

Hubungan antara Insulin-like Growth Factor-1 dengan Pertumbuhan dan Perkembangan Anak Sindrom Down

“…13 Beberapa penelitian menunjukkan kadar IGF-1 yang rendah pada anak sindrom Down, 14,15 tetapi ada pula yang menyatakan kadar IGF-1 masih dalam batas normal. 16 Penelitian Hestnes dan Ragusa menunjukkan bahwa kadar IGF-1 memiliki korelasi positif dengan usia, periode pubertas, dan tinggi badan, namun tidak berhubungan dengan BMI. 14,16,17 Selain perannya pada pertumbuhan, IGF-1 juga diketahui memiliki peran yang penting pada perkembangan otak, namun perannya terhadap perkembangan pada anak belum banyak diteliti.…”

“…16 Penelitian Hestnes dan Ragusa menunjukkan bahwa kadar IGF-1 memiliki korelasi positif dengan usia, periode pubertas, dan tinggi badan, namun tidak berhubungan dengan BMI. 14,16,17 Selain perannya pada pertumbuhan, IGF-1 juga diketahui memiliki peran yang penting pada perkembangan otak, namun perannya terhadap perkembangan pada anak belum banyak diteliti. 18,19 Penelitian ini bertujuan untuk membuktikan hubungan antara kadar IGF-1 terhadap pertumbuhan dan perkembangan anak dengan sindrom Down.…”