Somatomedin Inhibitors

Phillips, Lawrence S.; Goldstein, Steven; Klein, Janet D.

doi:10.1007/978-1-4684-5685-1_7

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E N D O C R I N E Role Of Igf-12

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1990

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“…1988;Suikkari et al 1988: Baxter & Martin. 1989) and inhibitors (Phillips et al 1989). The dynamics of regulation of these factors presently is best understood in terms of some of the IGF-binding proteins, of which the 25-kD form (BP-1) appears to be particularly sensitive to insulin and nutritional status.…”

Section: E N D O C R I N E Role Of Igf-1mentioning

confidence: 99%

“…Levels of BP-1 rise severalfold in patients with poorly controlled diabetes, and fall promptly with insulin therapy (Suikkari et al 1988). High molecular-weight (MW) IGF inhibitors appear to lower circulating IGFs bioactivity in diabetes, malnutrition, and steroid excess, while low-MW IGF inhibitors are more important in kidney failure (Phillips et al 1989).…”

Section: E N D O C R I N E Role Of Igf-1mentioning

confidence: 99%

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