Somatometric measurements, and clinical chemistry and hematology parameters in <scp>T</scp>ibetan macaque (<i><scp>M</scp>acaca thibetana</i>)

Wu, Di; Jiang, W.Y.; Yang, Feng-Ming; Wei, Shiyuan; Zhou, Liang; Yi, Yong; Wang, H.X.; Zhang, Y.A.; Feng, Yue

doi:10.1111/jmp.12062

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…Morphometric measurement is an important noninvasive means for evaluating body composition and nutritional status in both human and nonhuman primate physiological research [18]. In this study, we found a similar BMI and WHR between two species, both of which are important and widely used parameters for evaluating obesity in primate studies [19,20].…”

Section: Discussionsupporting

confidence: 54%

Comparative Features of Carotid and Cerebral Hemodynamics between Adult Rhesus Macaques and Humans

Liu¹,

Yang²,

Li³

et al. 2021

Advanced Ultrasound in Diagnosis and Therapy

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Although rhesus macaques and human beings share many fundamental biological characteristics, including underlying genes and physiological processes, the similarity and difference of cerebrovascular hemodynamic have not been well investigated. We aimed to examine and compare the intracranial and extracranial hemodynamics between these two species.Methods: A total of 10 adult male rhesus and 20 age-matched healthy men were recruited in this study. The somatometric measurements (BMI, HR, and BP) and ultrasonography examinations (carotid arteries and middle cerebral artery) were performed on both groups. Results:We found a few similarities in somatometric measurements (BMI, waist-hip ratio and mean artery pressure), mean velocity ratios of internal carotid artery (ICA)/external carotid artery (ECA) and ICA/vertebral artery (VA), and the resistance index both in ICA and ECA between rhesus macaques and humans. However, faster HR (103 ± 12 vs. 73 ± 14 beat/min, P < 0.01), higher pulse pressure (89.5 ± 8.9 vs. 48.1 ± 6.3 mmHg, P < 0.01), smaller diameter ratio of bilateral ICA/ECAdia (P < 0.01), elevated middle cerebral artery pulsatility index (P < 0.01) and higher cerebrovascular resistance (2.42 ± 0.59 vs. 1.54 ± 0.35, P < 0.01) were found in rhesus when compared with humans. Conclusions:This study leads to a better understanding of cerebral neuroanatomy in rhesus macaques, and it has several important implications for future cerebrovascular translational researches.

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Section: Discussionsupporting

confidence: 54%

Comparative Features of Carotid and Cerebral Hemodynamics between Adult Rhesus Macaques and Humans

Liu¹,

Yang²,

Li³

et al. 2021

Advanced Ultrasound in Diagnosis and Therapy

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“…In the MIT colony, this was found to be significantly different based on postpartum status, however, none of the UT Health animals included in this assessment were postpartum (Kramer et al, 2022). This difference has not been previously associated with age in marmosets, but reduction in amylase concentrations in Tibetan macaques is associated with age, with young animals having higher amylase concentrations than old animals (Wu et al, 2014), and seems to reflect pancreatic function across age groups.…”

Section: Discussionmentioning

confidence: 60%

Age‐related changes in hematological biomarkers in common marmosets

Hickmott,

Cervantes,

Arroyo

et al. 2023

American J Primatol

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Researchers and veterinarians often use hematology and clinical chemistry to evaluate animal health. These biomarkers are relatively easy to obtain, and understanding how they change across healthy aging is critical to clinical care and diagnostics for these animals. We aimed to evaluate how clinical biomarkers from a chemistry profile and complete blood count (CBC) change with age in common marmosets (Callithrix jacchus). We assessed blood samples collected during routine physical exams at the Southwest National Primate Research Center and the University of Texas Health San Antonio marmoset colonies from November 2020–November 2021. We found that chemistry and CBC profiles varied based on facility, sex, and age. Significant changes in albumin, phosphorus/creatinine ratio, albumin/globulin ratio, amylase, creatinine, lymphocyte percent, hematocrit, granulocytes percent, lymphocytes, hemoglobin, red cell distribution width, and platelet distribution width were all reported with advancing age. Aged individuals also demonstrated evidence for changes in liver, kidney, and immune system function compared with younger individuals. Our results suggest there may be regular changes associated with healthy aging in marmosets that are outside of the range typically considered as normal values for healthy young individuals, indicating the potential need for redefined healthy ranges for clinical biomarkers in aged animals. Identifying animals that exhibit values outside of this defined healthy aging reference will allow more accurate diagnostics and treatments for aging colonies.

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“…Thereby, it has great potential value in biomedical studies such as ophthalmology, obesity, metabolic disease, infectious disease, and organ transplantation (Liu et al, 2011;Ling et al, 2012;Yi et al, 2012). Recently, studies on the Tibetan macaque have primarily focused on its ethology (Zhao, 1997;Li et al, 2007;Xia et al, 2012Xia et al, , 2013, rearing, and disease prevention (Zhong et al, 2010;Wu et al, 2013). In molecular genetics, only a small number of studies on mitochondrial DNA (Li et al, 2008(Li et al, , 2009Yao et al, 2013a;Zhong et al, 2013), microsatellite DNA (Jia et al, 2011(Jia et al, , 2012, and immunity genes Yao et al, 2013b;Liu et al, 2013) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Sequence characterization and phylogenetic analysis of toll-like receptor (TLR) 4 gene in the Tibetan macaque (Macaca thibetana)

Dai

Yao

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In this study, the complete coding region sequence of an innate immune-related TLR4 gene was obtained from the Tibetan macaque (Macaca thibetana) genome via PCR and direct sequencing. The sequence had a total length of 2481 bp, contained 3 complete exons, and encoded 826 amino acids (AAs); its isoelectric point was 5.703, and the molecular weight was 94.72 kDa. The high structure prediction showed that the protein was comprised of one extracellular region, one transmembrane region, and one intracellular region. There were 48 potential functional sites in the protein, including glycosylation, phosphorylation, and acetylation sites. A homology analysis among 9 primate species, including the Tibetan macaque, human, chimpanzee, gibbon, rhesus macaque, cynomolgus monkey, pig-tailed monkey, squirrel monkey, and small-eared galago, showed that the homology of the nucleotide and AA sequences ranged from 60.9-99.5% and 51.4-99.0%, respectively. Higher variability was identified in the extracellular region of the TLR4 protein, and its variable sites accounted for 88.79% (AA) of the total variable sites. Additionally, the number of AAs at the 3' end of the intracellular region was notably different among the primate lineages. The phylogenetic tree based on TLR4 gene exons of 9 primate species showed that the Tibetan macaque clustered with the rhesus macaque, cynomolgus monkey, and pig-tailed monkey; it was most distant from the small-eared galago. This study will provide an important basis for further study on the expression, regulation, and polymorphism of the TLR4 gene and the relationship between polymorphisms and host disease susceptibility.

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Somatometric measurements, and clinical chemistry and hematology parameters in Tibetan macaque (Macaca thibetana)

Abstract: These physiological data will provide veterinarians and researchers with baseline values to evaluate experimental results using Tibetan macaques.

Cited by 5 publications

References 26 publications

Comparative Features of Carotid and Cerebral Hemodynamics between Adult Rhesus Macaques and Humans

Comparative Features of Carotid and Cerebral Hemodynamics between Adult Rhesus Macaques and Humans

Age‐related changes in hematological biomarkers in common marmosets

Sequence characterization and phylogenetic analysis of toll-like receptor (TLR) 4 gene in the Tibetan macaque (Macaca thibetana)

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