Somatosensory Deficits After Stroke: Insights From MRI Studies

Lv, Qiuyi; Zhang, Junning; Pan, Yuxing; Liu, Xiaodong; Miao, Linqing; Peng, Jing; Song, Lei; Zou, Yihuai; Chen, Xing

doi:10.3389/fneur.2022.891283

Cited by 7 publications

(7 citation statements)

References 180 publications

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“…For individuals affected by brain injuries, disruptions in somatosensory processing, including tactile perception, can significantly hinder their ability to perform everyday tasks. While tactile deficits correspond to poorer recovery in individuals with a brain injury, much remains to be learned about the neural mechanisms contributing to their deficits [5,7]. We designed and developed a novel tactile stimulator system that can interface with the fingers of individuals who have a brain injury to deliver force stimuli of varying magnitudes during fMRI.…”

Section: Discussionmentioning

confidence: 99%

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MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries

KalantaryArdebily,

Feldbush,

Gurari

2024

Preprint

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Accurate perception of tactile information is essential for performing activities of daily living and learning new sensorimotor skills like writing. Deficits in perceiving tactile stimuli are associated with severity in physical disability. The mechanisms contributing to tactile deficits in individuals with brain injuries remain poorly understood in part due to insufficient assessment methods. Here, we provide a tactile stimulator system for studying the neural mechanisms contributing to tactile deficits in individuals with brain injuries during functional magnetic resonance imaging (fMRI). This tactile stimulator system consists of a pneumatically-controlled inflatable and deflatable balloon that interfaces with a digit of the hand to provide small forces. The magnitude of the applied force is delivered and controlled by modifying the air pressure in the balloon. The tactile simulator provides an 8,mm diameter tactile stimulus. The device's interface at the finger is compact, allowing it to be used with individuals who have a closed-fist posture following brain injury such as stroke or cerebral palsy. The tactile stimulator contains no metallic components and can be used in MRI research. The tactile stimulator system can repeatedly apply a force between 1,N and 2.4,N. This tactile stimulator system addresses limitations in past fMRI methodologies for assessing tactile perception by providing precise and repeatable force stimuli to a small area of the finger. Custom software automates the application of the force stimuli and permits synchronization with acquired fMRI data. This system can be used in subsequent testing to investigate deficits in sensory functioning in those with brain injuries.

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Section: Discussionmentioning

confidence: 99%

“…This makes assessing tactile perception in this population particularly challenging as precise stimuli need to be delivered in a confined space. Existing reviews show limitations in current approaches to assess tactile stimulation in this population [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries

KalantaryArdebily,

Feldbush,

Gurari

2024

Preprint

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“…If somatosensory feedback is necessary to perform the motor task accurately, motor performance might decline due to a pure sensory deficit [ 80 ]. Therefore, the intact somatosensory system is crucial for recovering motor behaviour and improving other body functions [ 81 ]. Research on sensory recovery is limited.…”

Section: Discussionmentioning

confidence: 99%

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

Sahrizan

Manan

Hamid

et al. 2023

Cancers

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Working memory, language and speech abilities, motor skills, and visual abilities are often impaired in children with brain tumours. This is because tumours can invade the brain’s functional areas and cause alterations to the neuronal networks. However, it is unclear what the mechanism of tumour invasion is and how various treatments can cause cognitive impairment. Therefore, this study aims to systematically evaluate the effects of tumour invasion on the cognitive, language, motor, and visual abilities of paediatric patients, as well as discuss the alterations and modifications in neuronal networks and anatomy. The electronic database, PubMed, was used to find relevant studies. The studies were systematically reviewed based on the type and location of brain tumours, cognitive assessment, and pre- and post-operative deficits experienced by patients. Sixteen studies were selected based on the inclusion and exclusion criteria following the guidelines from PRISMA. Most studies agree that tumour invasion in the brain causes cognitive dysfunction and alteration in patients. The effects of a tumour on cognition, language, motor, and visual abilities depend on the type of tumour and its location in the brain. The alteration to the neuronal networks is also dependent on the type and location of the tumour. However, the default mode network (DMN) is the most affected network, regardless of the tumour type and location.Furthermore, our findings suggest that different treatment types can also contribute to patients’ cognitive function to improve or deteriorate. Deficits that persisted or were acquired after surgery could result from surgical manipulation or the progression of the tumour’s growth. Meanwhile, recovery from the deficits indicated that the brain has the ability to recover and reorganise itself.

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“…Sensory and motor alterations resulting from lesions in the central nervous system can impact interoception [ 15 ]. Interoception integrates signals from vital body systems (somatic, cardiovascular, gastrointestinal, and thermoregulatory) into conscious perception and regulation [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

Facciorusso,

Spina,

Picelli

et al. 2024

JCM

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Background/Objectives: This study examined the impact of spasticity-related unpleasant sensations (pain, heaviness, stiffness) on various domains of the International Classification of Functioning, Disability, and Health (ICF) and psychosocial well-being in individuals affected by stroke or traumatic brain injury (TBI). The primary aim is to explore how these sensations affect daily activities, participation, and overall quality of life, guided by the comprehensive framework of the ICF. Methods: Utilizing a secondary analysis of data from a cohort undergoing Botulinum toxin type-A treatment for spasticity post-stroke or TBI, we developed and administered an ad-hoc questionnaire focusing on ICF domains such as body function, activities and participation, and psychosocial aspects such as mood, relationship, social life, motivation, and sleep quality. Spearman rho correlation was applied to assess the relationship between unpleasant sensations and functional as well as psychosocial outcomes among 151 participants. Results: This study identified significant correlations between the severity of unpleasant sensations and limitations in daily functioning, particularly in activities of daily living and mobility. Furthermore, an impactful association was identified between increased unpleasant sensations and deterioration in psychosocial well-being, notably in mood and sleep quality. Conclusions: These findings advocate for a person-centered approach in spasticity management, emphasizing the integration of sensory impairment strategies into rehabilitation to enhance functional outcomes and quality of life. Such an approach aims to improve functional outcomes and enhance the quality of life for individuals experiencing spasticity post-stroke or TBI. Future directions include targeted interventions to alleviate these sensations, support better rehabilitation results and improve patient experiences.

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Somatosensory Deficits After Stroke: Insights From MRI Studies

Cited by 7 publications

References 180 publications

MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries

MR-Compatible Tactile Stimulator System: Application for Individuals with Brain Injuries

Functional Alteration in the Brain Due to Tumour Invasion in Paediatric Patients: A Systematic Review

May Spasticity-Related Unpleasant Sensations Interfere with Daily Activities in People with Stroke and Traumatic Brain Injury? Secondary Analysis from the CORTOX Study

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