Somatosensory evoked potentials induced by stimulating a variable number of nerve fibers in rat

Zhao, Shurun; Kim, Daniel H.; Kline, David G.; Beuerman, Roger W.; Thompson, Hilary W.

doi:10.1002/mus.880161112

Cited by 24 publications

(6 citation statements)

References 33 publications

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“…24,25 The amplitude of the evoked potentials reflects the number of synchronously activated axons and their excitability. 26 Therefore, these measures are sensitive to the number of preserved fibers in the dorsal columns. In our cohort, shorter SEP latencies and higher amplitudes were found in patients having wider dorsal midsagittal tissue bridges.…”

Section: Discussionmentioning

confidence: 99%

Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury

et al. 2019

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ObjectiveTo assess whether preserved dorsal and ventral midsagittal tissue bridges after traumatic cervical spinal cord injury (SCI) encode tract-specific electrophysiologic properties and are predictive of appropriate recovery.MethodsIn this longitudinal study, we retrospectively assessed MRI scans at 1 month after SCI that provided data on width and location (dorsal vs ventral) of midsagittal tissue bridges in 28 tetraplegic patients. Regression analysis assessed associations between midsagittal tissue bridges and motor- and sensory-specific electrophysiologic recordings and appropriate outcome measures at 12 months after SCI.ResultsGreater width of dorsal midsagittal tissue bridges at 1 month after SCI identified patients who were classified as being sensory incomplete at 12 months after SCI (p = 0.025), had shorter sensory evoked potential (SEP) latencies (r = −0.57, p = 0.016), and had greater SEP amplitudes (r = 0.61, p = 0.001). Greater width of dorsal tissue bridges predicted better light-touch score at 12 months (r = 0.40, p = 0.045) independently of baseline clinical score and ventral tissue bridges. Greater width of ventral midsagittal tissue bridges at 1 month identified patients who were classified as being motor incomplete at 12 months (p = 0.002), revealed shorter motor evoked potential (MEP) latencies (r = −0.54, p = 0.044), and had greater ratios of MEP amplitude to compound muscle action potential amplitude (r = 0.56, p = 0.005). Greater width of ventral tissue bridges predicted better lower extremity motor scores at 12 months (r = 0.41, p = 0.035) independently of baseline clinical score and dorsal tissue bridges.ConclusionMidsagittal tissue bridges, detectable early after SCI, underwrite tract-specific electrophysiologic communication and are predictors of appropriate sensorimotor recovery. Neuroimaging biomarkers of midsagittal tissue bridges may be integrated into the diagnostic workup, prediction of recovery, and patients' stratification in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury

et al. 2019

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“…Such an SSEP or evoked cortical potential indicated an intact dorsal root, although the results of animal studies have indicated that as few as 100 intact fibers can produce such a response. 58 If the SSEP or evoked cortical potential of the dorsal root was positive, there was usually, but not always, continuity to the ventral (motor) root. Recent work has advocated percutaneous magnetic stimulation of the motor strip and recording from the spinal nerve as a test of the integrity of the ventral root; however, our experience and that of others with this procedure are too nascent for inclusion in this series.…”

Section: Intraoperative Electrical Studiesmentioning

confidence: 99%

Outcomes of surgery in 1019 brachial plexus lesions treated at Louisiana State University Health Sciences Center

Kim¹,

Cho²,

Tiel³

et al. 2003

Journal of Neurosurgery

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213

142

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“…Previous data demonstrate good sensitivity but lower specificity of IOM, which correlates with the findings of this study. 27 Mixed IOM results more difficult to interpret. Twenty spinal nerves had either MEP+ or SSEP+ (not both), nine of which were grafted, with preference for MEP+ spinal nerves.…”

Section: Discussionmentioning

confidence: 98%

Factors Affecting C5 Viability and Demographic Variability in Two Brachial Plexus Centers

Zelenski

Joslyn

Lee

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Complete brachial plexus injuries are devastating injuries. A viable C5 spinal nerve can offer additional sources of axons and alter surgical treatment. We aimed to determine factors that portend C5 nerve root avulsion. Methods: A retrospective study of 200 consecutive patients with complete brachial plexus injuries at two international centers (Mayo Clinic in the United States and Chang Gung Memorial Hospital in Taiwan) was performed. Demographic information, concomitant injuries, mechanism, and details of the injury were determined, and kinetic energy (KE) and Injury Severity Score were calculated. C5 nerve root was evaluated by preoperative imaging, intraoperative exploration, and/or intraoperative neuromonitoring. A spinal nerve was considered viable if it was grafted during surgery. Results: Complete five-nerve root avulsions of the brachial plexus were present in 62% of US and 43% of Taiwanese patients, which was significantly different. Increasing age, the time from injury to surgery, weight, body mass index of patient, motor vehicle accident, KE, Injury Severity Score, and presence of vascular injury significantly increased the risk of C5 avulsion. Motorcycle (≤150cc) or bicycle accident decreased the risk of avulsion. Significant differences were found between demographic variables between the two institutions: age of injury, body mass index, time to surgery, vehicle type, speed of injury, KE, Injury Severity Score, and presence of vascular injury. Conclusions: The rate of complete avulsion injury was high in both centers. Although there are a number of demographic differences between the United States and Taiwan, overall the KE of the accident increased the risk of C5 avulsion.

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Somatosensory evoked potentials induced by stimulating a variable number of nerve fibers in rat

Cited by 24 publications

References 33 publications

Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury

Width and neurophysiologic properties of tissue bridges predict recovery after cervical injury

Outcomes of surgery in 1019 brachial plexus lesions treated at Louisiana State University Health Sciences Center

Factors Affecting C5 Viability and Demographic Variability in Two Brachial Plexus Centers

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