Somatostatin - A Regulatory Modulator Connecting Nutrient Entry and Metabolism

Schusdziarra,

doi:10.1055/s-2007-999203

Cited by 90 publications

(31 citation statements)

References 36 publications

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“…In addition, Barry et al (1985) have proposed that a major site of somatostatin action in lambs, infused with somatostatin for a prolonged period, was within the lower digestive tract where it may be involved in regulation of nutrient absorption. Similar findings have been reported for humans, dogs, and rats (Schusdziarra 1980). This resulted in a significant (P<0.03) treatment-by-time interaction (Fig.…”

supporting

confidence: 88%

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Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Christensen¹,

Christopherson²,

Kennelly³

1990

Can. J. Anim. Sci.

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supporting

confidence: 88%

“…Les (Brockman and Laarveld 1986;Schusdziarra 1980). In addition, Barry et al (1985) have proposed that a major site of somatostatin action in lambs, infused with somatostatin for a prolonged period, was within the lower digestive tract where it may be involved in regulation of nutrient absorption.…”

mentioning

confidence: 99%

Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Christensen¹,

Christopherson²,

Kennelly³

1990

Can. J. Anim. Sci.

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“…SRIF-LI is also present in D cells of the pancreatic islets (7) and throughout the gastrointestinal tract, with highest concentrations in the stomach (5,6). Pancreatic and gastrointestinal SRIF exert an important role in nutrient homeostasis (8). Pancreatic SRIF inhibits the release of insulin (9) and glucagon (10), possibly through a local or paracrine effect, thereby influencing nutrient disposition.…”

mentioning

confidence: 99%

Release of Somatostatin-like Immunoreactivity from Incubated Rat Hypothalamus and Cerebral Cortex

Berelowitz¹,

Dudlak²,

Frohman³

1982

J. Clin. Invest.

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A B S T R A C T Somatostatin (SRIF) is localized in the hypothalamus, extrahypothalamic brain, and throughout the gastrointestinal tract. Release of gastrointestinal SRIF-like immunoreactivity (SRIF-LI) is under nutrient regulation but the effect of nutrients on neural SRIF-LI is unknown. The present studies examined the effects of glucose uptake and metabolism and hormones influencing glucose disposition on SRIF-LI release from medial basal hypothalamus (MBH) and cerebral cortex (Cx) incubated in Krebs-Ringer bicarbonate containing bacitracin. After a preincubation to achieve stable secretion, tissues were incubated for 20 min in 14 mM glucose (basal) and then, for 20 min in fresh medium with test materials. MBH SRIF-LI release was inversely related to medium glucose concentration with release in the absence of glucose (235±42 pg/MBH per 20 min) more than five times that in the presence of 25 mM glucose (46±4 pg/20 min). In the presence of 14 mM glucose MBH SRIF-LI release was stimulated above basal by agents interfering with glucose uptake including 3-0-methyl-D-glucose (42 mM Cx SRIF-LI release was slightly inhibited by decreases in medium glucose and unaffected by inhibition of glucose uptake or metabolism. These results provide evidence for nutrient regulation of MBH but not Cx SRIF-LI release and may explain inhibition of growth hormone seen in the rat in response to hypoglycemia.Insulin (10 nM-1 gM) stimulated MBH but not Cx SRIF-LI release while glucagon was without effect. Our previous demonstration that MBH SRIF-LI release was stimulated by somatomedin-C, but not insulin at physiologic concentrations, is consistent with an action of insulin through the somatomedin-C receptor at the doses studied. Our studies indicate a regional specificity for the control of SRIF secretion within the brain and suggests the possibility of a role for hypothalamic SRIF in metabolic regulation.

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“…Johansson, Wisen, Efendic & Uvnas-Wallensten (1981) suggested that this might be explained by a decrease in intestinal absorption of those carbohydrates. Other authors (Schusdziarra, 1980;Brazeau, 1985) have shown that somatostatin inhibits this absorption.…”

Section: Sugar Absorptionmentioning

confidence: 92%

SOMATOSTATIN AND ITS ANALOGUE (D‐Trp⁸,D‐Cys¹⁴‐SOMATOSTATIN DO NOT MODIFY INTESTINAL ABSORPTION IN VIVO OF CARBOHYDRATES IN HAMSTER INTESTINE, BUT THEY DO MODIFY SOME DISACCHARIDASES

1989

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Somatostatin - A Regulatory Modulator Connecting Nutrient Entry and Metabolism

Cited by 90 publications

References 36 publications

Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Release of Somatostatin-like Immunoreactivity from Incubated Rat Hypothalamus and Cerebral Cortex

SOMATOSTATIN AND ITS ANALOGUE (D‐Trp⁸,D‐Cys¹⁴‐SOMATOSTATIN DO NOT MODIFY INTESTINAL ABSORPTION IN VIVO OF CARBOHYDRATES IN HAMSTER INTESTINE, BUT THEY DO MODIFY SOME DISACCHARIDASES

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Somatostatin - A Regulatory Modulator Connecting Nutrient Entry and Metabolism

Cited by 90 publications

References 36 publications

Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Effect of Somatostatin and Chronic Cold Exposure on Hormonal and Metabolite Concentration, Metabolic Rate, Thermoregulation, and Gut Motility in Sheep

Release of Somatostatin-like Immunoreactivity from Incubated Rat Hypothalamus and Cerebral Cortex

SOMATOSTATIN AND ITS ANALOGUE (D‐Trp8,D‐Cys14‐SOMATOSTATIN DO NOT MODIFY INTESTINAL ABSORPTION IN VIVO OF CARBOHYDRATES IN HAMSTER INTESTINE, BUT THEY DO MODIFY SOME DISACCHARIDASES

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SOMATOSTATIN AND ITS ANALOGUE (D‐Trp⁸,D‐Cys¹⁴‐SOMATOSTATIN DO NOT MODIFY INTESTINAL ABSORPTION IN VIVO OF CARBOHYDRATES IN HAMSTER INTESTINE, BUT THEY DO MODIFY SOME DISACCHARIDASES