Somatostatin administration alters taste preferences in the rat

Scalera, Giuseppe; Tarozzi, G

doi:10.1016/s0196-9781(98)00108-9

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…In preclinical studies, long‐term (25 days) peripheral administration of SST modifies food intake, body weight, gut motility and taste preference (Scalera & Tarozzi 1998a,b). Acute brain site‐specific activation of sst receptors in the neostriatum or ventral pallidum/substantia innominata decreases locomotion (Marazioti et al 2005; Tashev et al 2004) and in the pontine reticular nucleus blocks fear‐potentiated acoustic startle (Fendt et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression

Nanda

Roseboom

et al. 2008

Genes Brain and Behavior

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Psychological stressors precipitate and maintain stress-induced psychopathology, and it is likely that altered amygdala function underlies some of the deleterious effects of psychological stress. To understand the mechanisms underlying the linkage between the response to psychological stressors and maladaptive or psychopathological responses, we have focused on amygdala responsivity in animal models employing species-specific psychological stressors. In the present study, we characterized the effects of a 15-min exposure to a natural predator, the ferret, on rat behavior and the expression of the somatostatin family of genes in the amygdala. We examined the somatostatin family of genes because substantial evidence shows that central somatostatin systems are altered in various neuropsychiatric illnesses. We report that rats respond to acute ferret exposure with a significant increase in fearful and anxious behaviors that is accompanied by robust amygdala activation and an increase in somatostatin receptor 2 (sst2) messenger RNA expression within the amygdala and anterior cingulate cortex. These studies are the first to show stress-induced changes in amygdala sst2 expression and may represent one mechanism by which psychological stress is linked to adaptive and maladaptive behavioral responses.

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Section: Discussionmentioning

confidence: 99%

Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression

Nanda

Roseboom

et al. 2008

Genes Brain and Behavior

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“…The question of "why does SRIF treatment attenuate the anorectic effect due to imbalanced diet intake" may be answered specula-tively. It has been suggested that SRIF may have many inhibiting activities (5), and it has been shown that the intake of palatable sucrose and NaCl solution decreased whereas that of mildly aversive quinine and hydrochloride solution increased significantly in rats treated with SRIF (59). This behavior was explained by a general inhibitory action of SRIF on the central neural system subserving intake of either the palatable or aversive fluids.…”

Section: Discussionmentioning

confidence: 99%

“…6), and the development and maintenance of their normal morphological, physiological, and biochemical features depend on axonal transport of proteins in gustatory nerves (47), they might be altered by SRIF treatment and by a Bas diet or AA-imbalanced diet intake. In a previous paper (59), we demonstrated that SRIF treatment interferes with taste preferences and, to a certain extent, with taste bud distribution on the tongue. Moreover, protein nutrition after weaning is important to maintain taste sensitivity in humans (67) and taste preference and morphology of tongue epithelia in rats (1,45,46,48,49,50,(62)(63)(64).…”

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confidence: 81%

“…Four groups of rats were established in accordance with the baseline intake of the Bas for the following treatments: a Con group (n ϭ 6; treated with 0.5 ml/100 g body wt saline), a vehicle-injected group (n ϭ 6; treated with 0.5 ml/100 g body wt of the Protamine-Zn complex), a group treated with a low dose of SRIF (SRIF2, n ϭ 6; 2 g/100 g body wt), and a group with a relatively high dose of SRIF (SRIF8, n ϭ 6; 8 g/100 g body wt). Because Zn 2ϩ used to dissolve SRIF may play a role in supporting, nourishing, and differentiating taste buds (28), it was appropriate to use the following two groups of rats as Con: one injected with saline and the other with Protamine-Zn complex to check that the differences might be ascribed to possible changes in taste preferences (59). During SRIF treatments, rats were fed the Bas diet and drank water ad libitum.…”

Section: Methodsmentioning

confidence: 99%

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Somatostatin alters intake of amino acid-imbalanced diets and taste buds of tongue in rats

Scalera

2003

American Journal of Physiology-Regulatory, Integrative and Comp

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The present studies were designed to evaluate a potential dose-dependent effect of somatostatin (SRIF) administered peripherally on intake of either a low-protein basal diet or threonine-imbalanced diet (THR-IMB), on body weight gain (DeltaBW), gut motility, and on the histology of taste buds in rats. SRIF administration had a dual effect related to its concentration, increasing the intake of THR-IMB diet at low concentration and decreasing THR-IMB diet at high concentration. During the light phase, SRIF treatment increased the intake of THR-IMB diet, suggesting that the usual anorectic effect induced by intake of THR-IMB diet was attenuated. High-dosage SRIF decreases gastrointestinal motility, which, in turn, can decrease food intake and DeltaBW. The combination of THR-IMB diet regimen and SRIF treatment also induced significant modifications on the taste buds of the tongue. The feeding response to an amino acid-imbalanced diet includes a learned aversion to the diet, and animals may use taste in establishing that aversion. Modifications of taste buds of SRIF-treated rats eating THR-IMB diet might explain the increase of imbalanced diet intake if treated rats perceive this food as less aversive.

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“…In part, this ablation of growth hormone dynamics is attributable to a tamoxifen-induced increase of somatostatin release (Tannenbaum et al, 1992). Importantly, increased systemic levels of somatostatin have been implicated in altered feeding behavior (reviewed in Aponte et al, 1984), altered taste preferences in rats (Scalera and Tarozzi, 1998), and decreased food consumption in rodents and primates (Lotter et al, 1981). Alternate explanations for the lasofoxifene-mediated hypophagy have also been proposed , Terry et al, 2004, Weisenburger et al, 2004.…”

Section: Discussionmentioning

confidence: 99%

Embryo/fetal toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in rats and rabbits

Ozolins̆

Gupta²

2004

Birth Defects Research Pt B

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In general, both maternal and fetal effects of lasofoxifene were similar to those reported with other SERMs. Although the incidence or severity of these effects was, in some instances, greater in the rat than in the rabbit, the doses and the resultant maternal and fetal exposures were many orders of magnitude higher in the rat, suggesting the rabbit to be more sensitive to the toxicological effects of lasofoxifene.

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Somatostatin administration alters taste preferences in the rat

Cited by 6 publications

References 38 publications

Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression

Predator stress induces behavioral inhibition and amygdala somatostatin receptor 2 gene expression

Somatostatin alters intake of amino acid-imbalanced diets and taste buds of tongue in rats

Embryo/fetal toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in rats and rabbits

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