Somatostatin analogues for acute bleeding oesophageal varices

Pc, Gøtzsche; Hróbjartsson, Asbjørn

doi:10.1002/14651858.cd000193.pub2

Cited by 39 publications

(33 citation statements)

References 35 publications

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“…However, results of metaanalyses of trials of octreotide are controversial 35,100 and a more recent meta-analysis of trials of somatostatin analogues in general showed a negligible beneficial effect. 101 The reason octreotide alone may not be useful is because its administration has been associated with tachyphylaxis 102 and a more transient effect when compared to terlipressin. 103 However, as shown below, octreotide appears to be useful as an adjunct to endoscopic therapy.…”

Section: D2 Specific Measures To Control Acute Hemorrhage and Prevementioning

confidence: 99%

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

et al. 2007

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Section: D2 Specific Measures To Control Acute Hemorrhage and Prevementioning

confidence: 99%

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

et al. 2007

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“…Vapreotide is given as a 50 µg IV bolus followed by infusion of 50 µg per hour. However, results of meta-analyses of trials of octreotide are controversial (35,100) and a more recent meta-analysis of trials of somatostatin analogues in general showed a negligible beneficial effect (101). The reason octreotide alone may not be useful is because its administration has been associated with tachyphylaxis (102) and a more transient effect when compared to terlipressin (103).…”

Section: D2 Specific Measures To Control Acute Hemorrhage and Prevementioning

confidence: 99%

Prevention and Management of Gastroesophageal Varices and Variceal Hemorrhage in Cirrhosis

García–Tsao

Sanyal

Grace

et al. 2007

Am J Gastroenterology

631

753

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“…Several studies tried to find a mathematical relationship controlling patient survival. [1][2][3][4][5][6][7][8] This study had collected all the possible and available variables recorded during the period 2007-2008 in order to find all possible relationships. The results obtained showed that mortality is dependant on multiple factors.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately the evidence found was that Somatostatin analogues had significantly reduced the blood transfusion with undetectable impact on mortality. 8 All the above mentioned studies are driving more efforts to modulate the relationship between oesophageal varices and mortality in KAUH. These modalities can be used in clinical studies combined end-point instead of a single factor like direct mortality.…”

Section: Modelling Factors Causing Mortality In Oesophageal Varices Pmentioning

confidence: 99%

Modelling Factors Causing Mortality in Oesophageal VaricesPatients in King Abdul Aziz University Hospital

Bahlas

2009

OMJ

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Sami Bahlas (RC=1.80500, P-value 0.00014), total bilirubin (RC=0.01371, P-value 0.00016), direct bilirubin (RC=0.01298, P-value 0.00357, serum AST (RC=0.00914, P-value 0.00462), presence of at least bleeding event (RC=1.03373, P-value 0.00613), ascites grade I (RC=-1.57435, P-value 0.00967), SBP (RC=1.47216, P-value 0.01581), platelets count (RC=0.00398, P-value 0.03476) and oesophageal varices (RC = -1.42139, P-value 0.03673). Only 5 factors were likely to affect the mortality status. These factors were encephalopathy, spontaneous SBP, bleeding, ascites and grade of oesophageal varices. Six models were then formulated. Conclusion: These models should be retested in larger study groups to test their reliability in order to use them as surrogate end point in future clinical studies.

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Somatostatin analogues for acute bleeding oesophageal varices

Cited by 39 publications

References 35 publications

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis

Prevention and Management of Gastroesophageal Varices and Variceal Hemorrhage in Cirrhosis

Modelling Factors Causing Mortality in Oesophageal VaricesPatients in King Abdul Aziz University Hospital

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