Somatostatin immunoreactivity within the urinary bladder nerve fibers and paracervical ganglion urinary bladder projecting neurons in the female pig

Mazur, Urszula; Lepiarczyk, Ewa; Janikiewicz, Paweł; Bossowska, A.

doi:10.1016/j.jchemneu.2021.102007

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…Such ganglia have been described in the urinary bladder of humans, guinea pigs, and domestic pigs, and the largest number of them have been found in the urinary bladder trigone-the triangular-shaped region at the base of the bladder limitedly defined by the two ureteral orifices and the internal urethral meatus [23]. The urinary bladder is also innervated by the nerves of external origin, which are projections of the parasympathetic neurons located in the parasympathetic pelvic ganglia, sympathetic neurons located in sympathetic trunks, hypogastric plexuses, inferior mesenteric ganglia, as well as sensory neurons placed in the dorsal root ganglia [22,[24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs

Makowska,

Lech,

Gonkowski

2023

IJMS

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Bisphenol A (BPA), a substance globally used to produce plastics, is part of many everyday items, including bottles, food containers, electronic elements, and others. It may penetrate the environment and living organisms, negatively affecting, among others, the nervous, immune, endocrine, and cardiovascular systems. Knowledge of the impact of BPA on the urinary bladder is extremely scarce. This study investigated the influence of two doses of BPA (0.05 mg/kg body weight (b.w.)/day and 0.5 mg/kg b.w./day) given orally for 28 days on the neurons situated in the ganglia located in the urinary bladder trigone using the typical double immunofluorescence method. In the study, an increase in the percentage of neurons containing substance P (SP), galanin (GAL), a neuronal isoform of nitric oxide synthase (nNOS—used as the marker of nitrergic neurons), and/or cocaine- and amphetamine-regulated transcript (CART) peptide was noted after BPA administration. The severity of these changes depended on the dose of BPA and the type of neuronal factors studied. The most visible changes were noted in the cases of SP- and/or GAL-positive neurons after administering a higher dose of BPA. The results have shown that oral exposure to BPA, lasting even for a short time, affects the intramural neurons in the urinary bladder wall, and changes in the neurochemical characterisation of these neurons may be the first signs of BPA-induced pathological processes in this organ.

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Section: Introductionmentioning

confidence: 99%

Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs

Makowska,

Lech,

Gonkowski

2023

IJMS

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A diverse English keyword search reveals the value of scriptaid treatment for porcine embryo development following somatic cell nuclear transfer

Zheng

Yang

et al. 2022

Reprod. Fertil. Dev.

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Context Incomplete epigenetic reprogramming of histone deacetylation (HDAC) is one of the main reasons for the low efficiency of somatic cell nuclear transfer (SCNT). Scriptaid is a synthetic HDAC inhibitor (HDACi) that may improve the efficiency of porcine SCNT. Aims This study aimed to determine whether scriptaid increases the number of blastocyst cells or the cleavage rate. Methods We conducted a meta-analysis of the pertinent literature published over the past decade. Key results A total of 73 relevant papers were retrieved using a diverse English keyword search, and 11 articles were used for the meta-analysis. Scriptaid was positively correlated with blastocyst rate but had no effect on cleavage rate or blastocyst cell number. A subgroup analysis of blastocyst cell number showed that the staining method was the source of the heterogeneity. Conclusions In SCNT embryos, scriptaid treatment after activation can promote embryonic development, but there may be adverse effects on early development. Implications HDACi research should focus on SCNT birth efficiency.

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Somatostatin immunoreactivity within the urinary bladder nerve fibers and paracervical ganglion urinary bladder projecting neurons in the female pig

Cited by 2 publications

References 33 publications

Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs

Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs

A diverse English keyword search reveals the value of scriptaid treatment for porcine embryo development following somatic cell nuclear transfer

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