Somatostatin inhibits basal and growth hormone-stimulated hepatic insulin-like growth factor-I production

Very, Nicole M.; Kittilson, Jeffrey D.; Klein, Sarah E.; Sheridan, Mark A.

doi:10.1016/j.mce.2007.10.001

Cited by 33 publications

(27 citation statements)

References 43 publications

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“…Somatostatins previously were shown to inhibit GHR expression as well as basal and GH-stimulated IGF-I expression in the liver of rainbow trout (26,27). The present results confirm the effects of SSs on GHR and IGF expression and support our starting hypothesis that SS exerts its GHR-and IGF-inhibiting actions by specific activation of ERK and Akt signaling pathways in trout hepatocytes.…”

Section: Discussionsupporting

confidence: 90%

“…Further research on SSTR-effector system linkage is warranted to determine whether a particular SSTR subtype is responsible for ERK or Akt activation. It should be noted, however, that a broad range of both PPSS I-derived peptides and PPSS II-derived peptides, such as SS-25-II and SS-28-II, previously were found to inhibit GHR and GH-stimulated IGF-I expression in isolated trout hepatocytes (26,27), suggesting that ERK and Akt do not exclusively mediate the actions of SSs on these processes.…”

Section: Discussionmentioning

confidence: 95%

“…In particular, SS-14 reduces sensitivity to GH in rainbow trout hepatocytes by internalizing surface GH receptors (GHRs) and by decreasing transcription of GHR mRNAs (26). In addition, SS-14 reduces hepatic basal and GH-stimulated IGF-I production of rainbow trout in vivo and in vitro (27).…”

mentioning

confidence: 99%

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Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor I mRNA expression by activating the ERK and PI3K signaling pathways

Hagemeister

Sheridan²

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

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Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor I mRNA expression by activating the ERK and PI3K signaling pathways

Hagemeister

Sheridan²

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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“…ESTV_14714_122 is located near somatostatin receptor 5 (Table 4). High levels of somatostatin are known to reduce growth rates in rainbow trout by lowering plasma levels of growth hormone (GH), insulin‐like growth factor‐1 (IGF‐I), and insulin (Very, Kittilson, Klein, & Sheridan, 2008). Alleles that reduce levels of somatostatin might therefore be indirectly selected for under strong artificial selection for increased growth rates.…”

Section: Discussionmentioning

confidence: 99%

A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits

Liu

Ang

Elliott

et al. 2016

Evolutionary Applications

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Comparative genome scans can be used to identify chromosome regions, but not traits, that are putatively under selection. Identification of targeted traits may be more likely in recently domesticated populations under strong artificial selection for increased production. We used a North American Atlantic salmon 6K SNP dataset to locate genome regions of an aquaculture strain (Saint John River) that were highly diverged from that of its putative wild founder population (Tobique River). First, admixed individuals with partial European ancestry were detected using STRUCTURE and removed from the dataset. Outlier loci were then identified as those showing extreme differentiation between the aquaculture population and the founder population. All Arlequin methods identified an overlapping subset of 17 outlier loci, three of which were also identified by BayeScan. Many outlier loci were near candidate genes and some were near published quantitative trait loci (QTLs) for growth, appetite, maturity, or disease resistance. Parallel comparisons using a wild, nonfounder population (Stewiacke River) yielded only one overlapping outlier locus as well as a known maturity QTL. We conclude that genome scans comparing a recently domesticated strain with its wild founder population can facilitate identification of candidate genes for traits known to have been under strong artificial selection.

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“…The regulation of GH by SST may be influenced by developmental stage, feeding, and nutritional state [84,85]. Other research suggests that SSTs are involved in the regulation of growth hormone sensitivity of fish hepatocytes, and can cause a reduction in the levels of GHR expression and IGF-1 biosynthesis and secretion [86,87]. SSTR2 activation is linked to inhibition of pituitary GH release in fish [88].…”

Section: Growth Hormone Inhibiting Hormone (Ghih or Somatostatin Sst)mentioning

confidence: 99%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth. Among the possible growth-regulating pathways in vertebrates, components of the somatotropic axis are thought to have the greatest influence. There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish. This includes research into growth hormone, upstream hypothalamic hormones, insulin-like growth factors, and downstream signaling molecules. Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism. Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo. In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis, including emerging research using genetic modified models. These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. somatic growth, endocrine regulation, fish Citation:

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Somatostatin inhibits basal and growth hormone-stimulated hepatic insulin-like growth factor-I production

Cited by 33 publications

References 43 publications

Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor I mRNA expression by activating the ERK and PI3K signaling pathways

Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor I mRNA expression by activating the ERK and PI3K signaling pathways

A genome scan for selection signatures comparing farmed Atlantic salmon with two wild populations: Testing colocalization among outlier markers, candidate genes, and quantitative trait loci for production traits

Neuroendocrine regulation of somatic growth in fishes

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