Somatostatin inhibits insulin‐like growth factor‐I receptor expression in the gill of a teleost fish (Oncorhynchus mykiss)

Abstract

Rainbow trout gill tissue was

Somatostatin inhibits hepatic growth hormone receptor and insulin-like growth factor I mRNA expression by activating the ERK and PI3K signaling pathways

“…In addition, SS inhibited basal and GH-stimulated IGF-I production (12,27). At the level of the other target organs such as the gill, SS inhibited mRNA and functional expression of IGF-I receptors (25). Such local controls help explain differential responsiveness of tissues during embryonic and postembryonic growth.…”

Identification, Expression, and Functions of the Somatostatin Gene Family in Spotted Scat (Scatophagus argus)

“…To explore the effect of SST on growth functions, the effects of four SST peptides on Igf-1 and Igf-2 expression in S. argus liver fragments were investigated. In Oncorhynchus kisutch, stimulation of SST expression in the hypothalamus impeded hepatic Igf-1 expression [49,50]. In vitro culture of O. mykiss hepatocytes in the presence of SS-14 inhibited Igf-1 expression [7].…”

Growth regulation in brook charr Salvelinus fontinalis

“…GH, which is synthesized by the pituitary gland, regulates many functions, including somatic growth, energy metabolism, reproduction, digestion, osmoregulation, and immune function (Kawaguchi et al, 2013). The release and synthesis of GH in the brain and peripheral tissues are i) stimulated by neuroendocrine factors, such as neuropeptide Y (NPY) (Aldegunde and Mancebo, 2006) and ghrelin (GRL) (Rønnestad, et al, 2017;Perelló-Amorós et al, 2018), and ii) inhibited by somatostatin (SRIF, mainly synthesized in the brain) (Nelson and Sheridan, 2005;Very and Sheridan, 2007;Sheridan and Hagemeister, 2010;Volkoff et al, 2010). GH stimulates the production of liver IGF-1 (Volkoff et al, 2010), so its physiological effects are usually indirect, via IGF-1 actions.…”