Somatostatin: Its Influence on Plasma Levels of Growth Hormone, Prolactin and Thyrotropin in Sheep

“…GH response to an acute GHRH stimulation was even lower in the anti-SRIH group than in the control group, suggesting that SRIH could be involved in GH regulation through the prevention of GH stores depletion and/or GHRH receptor desensitization (12,13). Previous reports have shown that very high doses of somatostatin are required to inhibit basal and stimulated GH secretion in the sheep (14)(15)(16)(17). These data suggest important interspecies differences in the physiological involvement of SRIH at the pituitary level.…”

Section: Introductionmentioning

confidence: 99%

Species differences between male rat and ram pituitary somatostatin receptors involved in the inhibition of growth hormone secretion

Briard

Dutour

Epelbaum

et al. 1997

European Journal of Endocrinology

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The sheep is a valuable model in which to study GH neuroregulation as its pattern of GH secretion is very close to that in humans. Furthermore, important differences in somatostatin (SRIH) action between rats and sheep have been found previously. Our goal was to compare in male rat and ram pituitaries the binding characteristics of somatostatin receptors and the effect of SRIH and 17 analogues on GH release. Using radioautography, SRIH binding was seen to be evenly distributed over the anterior pituitary of both species. In the binding assay, binding sites were three times more concentrated in rats than in sheep. Important interspecies differences in the action of SRIH and its analogues were found: they inhibited GH at lower concentrations in rats than in sheep. Seven peptides displayed greater inhibitory ability in sheep than in rats while three were more potent in rats. Agonistic potencies to inhibit GH release in rats were correlated with somatostatin receptors subtype 2 (sst2) affinities. Our data confirm and extend the quantitative differences between rat and sheep in SRIH inhibitory action on GH secretion and confirm that ligand-binding properties of a given receptor subtype cannot be extrapolated across species. European Journal of Endocrinology 137 545-555

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“…2) or arginine (Fig. 3) (Davis 1975 (Reichlin 1983). The possibility that the growth-promoting effect of immunization against somatostatin was mediated by differences in voluntary feed intake alone can not be ruled out.…”

mentioning

confidence: 99%

Somatostatin Immunization and Growth of Lambs

Laarveld¹,

Chaplin²,

Kerr³

1986

Can. J. Anim. Sci.

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Somatostatin: Its Influence on Plasma Levels of Growth Hormone, Prolactin and Thyrotropin in Sheep

Cited by 34 publications

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EVIDENCE OF a ROLE FOR GLUCAGON IN REGULATING GLUCOSE AND Β-Hydroxybutyrate METABOLISM IN SHEEP

EVIDENCE OF a ROLE FOR GLUCAGON IN REGULATING GLUCOSE AND Β-Hydroxybutyrate METABOLISM IN SHEEP

Species differences between male rat and ram pituitary somatostatin receptors involved in the inhibition of growth hormone secretion

Somatostatin Immunization and Growth of Lambs

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