Somatostatin plasma levels and biological effects following subcutaneous administration of somatostatin in man

Abstract

The rate at which somatostatin appears in the circulation after subcutaneous bolus injection and continuous administration by pump was determined in normal subjects by serial radioimmunoassays of immunoreactive somatostatin. Following a single subcutaneous injection of 250 \g=m\g, the somatostatin peak in plasma appeared after 5 min and had only a transient effect on insulin levels. During continuous administration, somatostatin reached levels able to reduce significantly insulin and glucagon. Somatostatin plasma levels exerting biological effects were observed during the subcutaneous administration of the peptide.

Hormonal and Metabolic Responses to Cholecystectomy: Comparison of Extradural Somatostatin and Diamorphine

“…The increase in plasma concentration of glycerol after 60 min of surgery in the somatostatin patients may have resulted from the suppression of insulin secretion, as this hormone is a potent inhibitor of lipolysis. A study of the hormonal effects of the subcutaneous injection of somatostatin 250 ug showed a transient reduction in plasma insulin [27]. During a continuous i.v.…”