Somatostatin Receptor as a Molecular Imaging Target in Human and Canine Cushing Disease

Ravin, Emma De; Phan, Hoang; Harmsen, Stefan; Cho, Steve S.; Teng, Clare W; Petersson, E. James; White, Caitlin; Galban, Evelyn M.; Hess, Rebecka S.; Lee, John Y.K.

doi:10.1016/j.wneu.2021.02.034

Cited by 2 publications

(3 citation statements)

References 56 publications

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“…This variation in normal biodistribution of the 68 GA-DOTATATE tracer should be taken into consideration when ordering and interpreting the findings of these scans. In addition, more recent studies have identified higher expression of SSTR type 3 and 5 than SSTR type 2 on ACTH-secreting pituitary tumors [29,34]. Thus 68 GA-DOTANOC, which employs tracers with higher affinity to both SSTR type 3 and 5, may be a superior imaging modality than 68 GA-DOTATATE [30,33,35].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Adrenocorticotropic Hormone-Secreting Pituitary Carcinoma: A Case Report and Review of the Literature

et al. 2021

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Adrenocorticotropic hormone (ACTH)-secreting pituitary carcinomas (PC) are rare. The natural history and management of these carcinomas are poorly understood. We conducted a literature review using The MEDLINE database, including the search terms; ‘ACTH’ and ‘pituitary carcinoma’. We also describe in detail a case of ACTH-secreting PC. A total of 61 case reports were reviewed. Median age of diagnosis was 45 years (IQR: 34–54). Metastases to multiple organs were common (61%). Adjuvant therapy especially radiotherapy (78%), temozolomide (34%) and other medical therapy (29%) were frequently employed. The mortality was 53% with a median time to death from diagnosis of 1 year (IQR: 1–3). In conclusion, ACTH-secreting PC are associated with high mortality and a multidisciplinary team approach is recommended for optimal care due to the emerging modalities with possible efficacy.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and Management of Adrenocorticotropic Hormone-Secreting Pituitary Carcinoma: A Case Report and Review of the Literature

et al. 2021

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Section: Introductionmentioning

confidence: 99%

“…29,30 At present, several FIGS agents based on macromolecules (antibodies), peptides, and small molecules have been developed, and some of the candidates have progressed to clinical trials. These agents were designed to target several molecular biomarkers, such as epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR), 31 gastrin-releasing peptide receptor (GRPR), 32 somatostatin receptor 5 (SSTR5), 33 and the cluster of differentiation 24 (CD-24). 34 Although RGS and FIGS methods have experienced significant growth in recent decades, with a broad number of targeted receptors being studied, the exploration of TSPO as a potential molecular target in surgical oncology is still limited.…”

Section: Introductionmentioning

confidence: 99%

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers

Wongso,

Kurniawan,

Setiadi

et al. 2023

Adv Pharm Bull

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Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified as the peripheral benzodiazepine receptor (PBR). TSPO involves in a broad number of biochemical events, such as steroidogenesis, mitochondrial cholesterol transport, cell survival and death, cell proliferation, and carcinogenesis. Several investigations have reported the roles of TSPO in various types of cancers, including colorectal cancer, brain cancer, melanoma, breast cancer, prostate cancer, and lung cancer. It was found that TSPO is upregulated in cancer cells, and it appears that its expression is parallel with an aggressive phenotype and/or poor prognosis. As a consequence, there is great potential for developing diagnostic and prognostic tools targeting the TSPO. In this regard, several radioligands targeting the TSPO have been identified, and some of the candidates have advanced to clinical trials. In recent years, image-guided surgery using hybrid probes bearing radioactive and fluorescence molecules has demonstrated promising outcomes in animal and human studies, and thus might serve as a valuable surgical navigator during cancer surgery. In general, current hybrid probes are built from various molecular platforms, including small molecules, nanoparticles, and antibodies. Although several TSPO-targeted imaging probes have been developed, their development for image-guided surgery of cancers is scarce. This review highlights recent findings of the involvement of TSPO in carcinogenesis, and provides a new perspective on the potential application of TSPO-targeted hybrid probes for image-guided surgery.

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Somatostatin Receptor as a Molecular Imaging Target in Human and Canine Cushing Disease

Cited by 2 publications

References 56 publications

Diagnosis and Management of Adrenocorticotropic Hormone-Secreting Pituitary Carcinoma: A Case Report and Review of the Literature

Diagnosis and Management of Adrenocorticotropic Hormone-Secreting Pituitary Carcinoma: A Case Report and Review of the Literature

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers

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