Somatostatin receptor scintigraphy with 111In-pentetreotide in non-functioning gastroenteropancreatic neuroendocrine tumors

Schillaci, Orazio; Spanu, Angela; Scopinaro, Francesco; Falchi, Antonio; Corleto, Vito D.; Danieli, Roberta; Marongiu, Pietro; Pisu, Nicola; Madeddu, Giordano; Fave, Gianfranco Delle; Madeddu, Giuseppe

doi:10.3892/ijo.23.6.1687

Cited by 52 publications

(62 citation statements)

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“…90% for non-functioning tumours. Scintigraphy with the use of 111 In-Octreoscan enables the ability to detect approximately 90% of GEP NENs hepatic metastases [90]. Generally, the sensitivity of SRS is estimated to be 71-96% [91], whereas the specificity ranges between 76% and 95% [89,91].…”

Section: Radioisotope Diagnosticsmentioning

confidence: 99%

“…The results of the 90 Y/ 177 Lu DOTA TOC therapy in a group of 20 patients, including 15 with PNEN, were presented in 2006. Regarding the patients with PNEN, the authors observed stabilisation of the disease in eight patients, partial remission in four patients, and progression of the disease in three patients [143].…”

Section: Radioisotope Treatmentmentioning

confidence: 99%

“…Recent reports point to the possibility of using PRRT much earlier, before the surgery of unresectable lesions, mostly in the case of PNENs. The authors used both 90 …”

Section: Radioisotope Treatmentmentioning

confidence: 99%

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Nowotwory neuroendokrynne trzustki — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Kos–Kudła

Rosiek²,

Borowska

et al. 2014

Endokrynologia Polska

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We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by the Polish Network of Neuroendocrine Tumours. These guidelines refer to biochemical (determination of specific and nonspecific neuroendocrine markers) and imaging diagnostics (EUS, CT, MR, and radioisotope examination with a 68 Ga or 99Tc labelled somatostatin analogue). A histopathological diagnostic, which determines the further management of patients with PNENs, must be necessarily confirmed by immunohistochemical tests. PNENs therapy requires collaboration between a multidisciplinary team of specialists experienced in the management of these neoplasms. Surgery is the basic form of treatment. Medical therapy requires a multidirectional procedure, and therefore the rules of biotherapy, peptide receptor radionuclide therapy, chemotherapy and molecular targeted therapy are discussed.

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Section: Radioisotope Diagnosticsmentioning

confidence: 99%

Section: Radioisotope Treatmentmentioning

confidence: 99%

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Nowotwory neuroendokrynne trzustki — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Kos–Kudła

Rosiek²,

Borowska

et al. 2014

Endokrynologia Polska

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“…In this implementation low-energy cancer tracers [3,5] are assumed since they require small and thus light collimators (for energies below ≈ 250 [keV ] only a couple of millimeters of lead are sufficient for shielding). Unfortunately this leaves out the possibility of using the system with several successful cancer tracers like F -18-FDG, due to their high-energy nature (energy above 400 [keV ], where some centimeters of lead are needed for effective shielding).…”

Section: Discussionmentioning

confidence: 99%

“…A prime candidate for this is nuclear imaging, as there are tracers with high specific uptake in liver metastases [4], and in general this modality features low false-positive detection rates [5] in pre-operative diagnostics.…”

Section: Motivationmentioning

confidence: 99%

Real-Time Fusion of Ultrasound and Gamma Probe for Navigated Localization of Liver Metastases

Wendler¹,

Feuerstein²,

Traub³

et al. 2007

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007

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Abstract. Liver metastases are an advanced stage of several types of cancer, usually treated with surgery. Intra-operative localization of these lesions is currently facilitated by intra-operative ultrasound (IOUS) and palpation, yielding a high rate of false positives due to benign abnormal regions. In this paper we present the integration of functional nuclear information from a gamma probe with IOUS, to provide a synchronized, real-time visualization that facilitates the detection of active metastases intra-operatively. We evaluate the system in an ex-vivo setup employing a group of physicians and medical technicians and show that the addition of functional imaging improves the accuracy of localizing and identifying malignant and benign lesions significantly. Furthermore we are able to demonstrate that the inclusion of an advanced, augmented visualization provides more reliability and confidence on classifying these lesions in the presented evaluation setup. MotivationLiver metastases are a common consequence of cancer cells spreading from primary tumors. Surgical resection is the indicated therapy if possible, as it results in a cure with high probability [1]. To facilitate extraction, intra-operative localization of the tumorous regions is achieved by a combination of palpation and intra-operative ultrasound (IOUS). This technique is considered the gold standard as it has been in successful clinical practice for years already with a proved high sensitivity [2,3]. However, in the presence of benign abnormal structures, a considerable false-positive detection rate still remains. These abnormalities may be cysts, hemangiomas, scar tissue, or even metastases, which were previously diagnosed by e.g. PET/CT and treated successfully with chemotherapy or other neoadjuvant therapies [3]. This problem, although reduced, is still present when using contrast-enhanced ultrasound [2], which has a promising potential for better image quality, but still remains a mostly anatomical imaging modality.To reduce the detection rate of false-positives, the integration of a functional modality to complement the standard localization technique is a promising approach. A prime candidate for this is nuclear imaging, as there are tracers with

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Treatment of liver metastases from neuroendocrine tumours in relation to the extent of hepatic disease

Frilling

Malamutmann

et al. 2009

British Journal of Surgery

223

195

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Somatostatin receptor scintigraphy with 111In-pentetreotide in non-functioning gastroenteropancreatic neuroendocrine tumors

Cited by 52 publications

References 0 publications

Nowotwory neuroendokrynne trzustki — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Nowotwory neuroendokrynne trzustki — zasady postępowania (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)

Real-Time Fusion of Ultrasound and Gamma Probe for Navigated Localization of Liver Metastases

Treatment of liver metastases from neuroendocrine tumours in relation to the extent of hepatic disease

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