Somatostatin receptor subtypes: basic pharmacology and tissue distribution

Corleto, Vito D.; Nasoni, S.; Panzuto, Francesco; Cassetta, S.; Fave, Gianfranco Delle

doi:10.1016/j.dld.2003.11.008

Cited by 32 publications

(28 citation statements)

References 54 publications

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“…This substance is an active factor widely distributed in the body of all vertebrates and some invertebrate species, which can be produced by neurons, neuroendocrine, inflammatory and immune cells (18). Functions of somatostatin are mediated by five types of receptors (sst1-5), all of which are members of the G protein coupled receptor superfamily (8). In spite of the fact that physiological functions of SOM are relatively well established, some aspects of its action remain not clear.…”

Section: Introductionmentioning

confidence: 99%

Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Gonkowski

2014

Bulletin of the Veterinary Institute in Pulawy

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Retrograde neuronal tracing, using fast blue, in combination with a single-labelling immunofluorescence technique, was applied to determine whether somatostatin (SOM) participates in sensory innervating of the porcine adrenal glands in physiological conditions and after adrenalectomy. In control animals, SOM-like immunoreactive neurons comprised 7.0 ± 0.7% of adrenal gland-projecting cells in dorsal root ganglia (DRG) at neuromeres Th6-7 and 6.5 ± 1.2% at neuromeres Th12-14. After adrenalectomy the percentage of SOM-positive DRG cells considerably increased and attained the level of 44.7 ± 2.5% at neuromeres Th6-7 and 36.6 ± 1.7% at neuromeres Th12-14. The obtained results demonstrate that SOM is not only a neuromediator within sensory neurones supplying the porcine adrenal glands, but also suggest the role of this substance during repairing processes within the nervous system after adrenalectomy.

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Section: Introductionmentioning

confidence: 99%

Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Gonkowski

2014

Bulletin of the Veterinary Institute in Pulawy

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“…Additionally, it causes a reduction of gastrointestinal tract motility and gallbladder contractility and plays a regulatory role in the immune system [1,2,3]. The biological functions of somatostatin are mediated via a family of G-protein-coupled receptors, sst 1 to sst 5 .…”

Section: Introductionmentioning

confidence: 99%

Reassessment of sst<sub>3</sub> Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-5

Lupp

Nagel²,

Doll³

et al. 2012

Neuroendocrinology

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Background: Among the five somatostatin receptors (sst₁-sst₅), the sst₃ receptor displays a distinct pharmacological profile. Like sst₂, the sst₃ receptor efficiently internalizes radiolabeled somatostatin analogs. Unlike sst₂, however, internalized sst₃ receptors are rapidly transferred to lysosomes for degradation. Apart from this, very little is known about the clinical relevance of the sst₃ receptor, which may in part be due to the lack of specific monoclonal sst₃ antibodies. Methods: Here, we have extensively characterized the novel rabbit monoclonal anti-human sst₃ antibody UMB-5 using transfected cells and receptor-expressing tissues. UMB-5 was then subjected to immunohistochemical staining of a series of 190 formalin-fixed, paraffin-embedded normal and neoplastic human tissues. Results: Specificity of UMB-5 was demonstrated by detection of a broad band migrating at a molecular weight of 70,000–85,000 in immunoblots from human pituitary. After enzymatic deglycosylation, the size of this band decreased to a molecular weight of 45,000. Tissue immunostaining was completely abolished by pre-adsorption of UMB-5 with its immunizing peptide. In addition, UMB-5 detected distinct cell populations in human tissues like pancreatic islands, anterior pituitary, adrenal cortex, adrenal medulla, and enteric ganglia, similar to that seen with a rabbit polyclonal antibody generated against a different carboxyl-terminal epitope of the sst₃ receptor. In a comparative immunohistochemical study, UMB-5 yielded predominant plasma membrane staining in the majority of pituitary adenomas, pheochromocytomas, and a subset of neuroendocrine tumors. The sst₃ receptor was also present in many glioblastomas, pancreatic, breast, cervix, and ovarian carcinomas. Conclusion: The rabbit monoclonal antibody UMB-5 may prove of great value in the identification of sst₃-expressing tumors during routine histopathological examinations. Given its unique trafficking properties, these tumors may be potential candidates for sst₃-directed receptor radiotherapy.

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“…It is a tetradecapeptide (14 amino acids) that was isolated for the first time in 1973 from the ovine hypothalamus and was demonstrated to inhibit growth hormone secretion (Brazeau et al 1973), which is secreted by D type of endocrine cells (Tzaneva 2003). Within the GI tract SOM plays multiple roles mediated by six types of receptors, all of which are members of the G protein coupled receptor superfamily and which are involved in various intracellular signaling pathways (for review, see Corleto et al, 2004). First of all SOM is known as the major inhibitory mediator of gastric acid release (Komasaka et al 2002).…”

Section: Introductionmentioning

confidence: 99%

The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon

Gonkowski

Calka

2012

Pesq. Vet. Bras.

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Somatostatin receptor subtypes: basic pharmacology and tissue distribution

Cited by 32 publications

References 54 publications

Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Somatostatin-like immunoreactive primary sensory neurons supplying the porcine adrenal glands in physiological conditions and after adrenalectomy

Reassessment of sst<sub>3</sub> Somatostatin Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-5

The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon

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