Somatostatin receptors as a new active targeting sites for nanoparticles

Abstract

The delivery of nanoparticles through receptor-mediated cell interactions has nowadays a major attention in the area of drug targeting applications. This specific kind of targeting is mediated by localized receptors impeded into the target site with subsequent drugs internalization. Hence, this type of interaction would diminish side effects and enhance drug delivery efficacy to the target site. Somatostatin receptors (SSTRs) are one type of G protein-coupled receptors, which could be active targeted for various purposes. There are five SSTRs types (SSTR1-5) which are localized at various organs in the body and spread into different tissues. SSTRs could be considered as a promising target to various nanoparticles which is facilitated when nanoparticles are modified through specific ligand or coating to allow better binding. This review discusses the exploration of SSTRs for active targeting of nanoparticles with certain emphasize on their interaction at the cellular level.

Recent updates in COVID-19 with emphasis on inhalation therapeutics: Nanostructured and targeting systems

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“…The possible uses of anticoagulation in COVID-19 could be of attention, such as anticoagulants heparin can be conjugated to NPs potentially as anti-viral activities against COVID-19 [ 116 ]. Moreover, NPs can transport anticoagulants to specific cells which offer controlled-release therapy [ 108 ]. These anticoagulant drugs can be inhaled, absorbed through the skin transdermal, and or injected.…”

Peptide Receptor Radionuclide Therapy and Primary Brain Tumors: An Overview

“…A high variety of physiological functions are regulated by this hormone; furthermore, it presents inhibitory effects on the secretion of other hormones. The function of somatostatin is mediated by SSTR, a type of G-protein-coupled receptor [ 49 ]. These receptors are physiologically expressed in healthy tissues and organs such as the central and peripheral nervous system, pancreas and gastrointestinal tract, salivary glands and vessels, stimulating cell proliferation as well.…”

Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art

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