Somatostatin receptors in the haematopoietic system

Oomen, SP; Hofland, L. J.; Hagen, PM van; Lamberts, S. W. J.; Touw, I.P.

doi:10.1530/eje.0.143s009

Cited by 31 publications

(15 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the bleomycin mouse model, increased expression of sst2 was due, at least in part, to an influx of inflammatory cells, particularly monocytes and macrophages. Expression of sst2 has been shown to be upregulated in activated monocytes 14. Our results support data indicating that somatostatin analogues exert anti-inflammatory effects on lymphocytes, macrophages and neutrophils 15 – 20.…”

Section: Discussionsupporting

confidence: 88%

Activation of somatostatin receptors attenuates pulmonary fibrosis

Borie

Fabre

Prost

et al. 2008

Thorax

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 88%

Activation of somatostatin receptors attenuates pulmonary fibrosis

Borie

Fabre

Prost

et al. 2008

Thorax

View full text Add to dashboard Cite

show abstract

“…The spleen has not been studied in depth but, PCR studies show that the spleen expresses both sst 2 and sst 3 , whereas the human bone marrow expresses only sst 2 (Oomen et al, 2000).…”

Section: Cortistatin Somatostatin and Their Receptors In The Human Imentioning

confidence: 99%

“…Expression of SRIF and cortistatin (CST) and their receptors in the human immune system and malignancies of the immune system (Dalm et al, 2003b;Dalm et al, 2004a;Dalm et al, 2003c;Dalm et al, 2004b;Ferone et al, 2004;Ferone et al, 2002;Lichtenauer-Kaligis et al, 2004;Oomen et al, 2000;ten Bokum et al, 2000;ten Bokum et al, 1999a;ten Bokum et al, 1999c;van Hagen et al, 1999 A c c e p t e d M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t M a n u s c r i p t…”

Section: Page 13 Of 20mentioning

confidence: 99%

The role of cortistatin in the human immune system

Hagen

Dalm

Staal

et al. 2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Please cite this article as: van Hagen, P.M., Dalm, V.A., Staal, F., Hofland, L.J., The Role of Cortistatin in the Human Immune System, Molecular and Cellular Endocrinology (2007Endocrinology ( ), doi:10.1016Endocrinology ( /j.mce.2008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCortistatin (CST) is a recently described neuropeptide that shares high homology with somatostatin (somatotropin release-inhibiting factor, SRIF) and binds with high affinity to all somatostatin receptor (sst) subtypes. CST is currently known to have a widespread distribution in many human organs including the immune system. The activities specific to CST may be partially attributable to its binding to the growth hormone secretagogue (GHS) receptor (GHS-R) and the orphan Gprotein-coupled receptor MrgX2. Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst 2 , and human lymphocytes express sst 3 . The human thymus expresses sst 1,2,3 , MrgX2 and almost all immune cells express GHS-R. Moreover, at this very moment promising research with CST in experimental animal models is being performed. On the basis of these promising results, studies aiming to further evaluate the possibilities of CST as a therapeutic agent in human immune mediated inflammatory diseases are warranted.

show abstract

“…This suggests that SST may have an effect on the homing and migration of T cells [172,178]. The unique migration-inducing effects of SST-SSTRs on hematopoietic progenitor cells homing and trafficking to various organs may play a crucial role during the development of diseases.…”

Section: Sst and Sstrs In Type 1 Diabetesmentioning

confidence: 99%

“…Previous analysis demonstrated that by using SSTR-specific antagonists and agonists, SST peptides specifically interact with subtype-specific receptors on T cells leading to adhesion. Using octreotide and CD34 + progenitor cells as a model system, scientists have discovered that SST peptides are able to induce migration of SSTR-specific stem cells with chemoattractant activity, as well as chemokinetic activity, suggesting that SST may have an effect on the homing and migration of T cells [172,178]. Results have shown that SSTR2-specific CD34 + progenitor cells induce cell migration via phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase pathways [172].…”

Section: Sst and Sstrs In Type 1 Diabetesmentioning

confidence: 99%

Somatostatin receptors and autoimmune‐mediated diabetes

Wang

Norman

Brunicardi

2004

Diabetes Metabolism Res

View full text Add to dashboard Cite

Somatostatin (SST) peptide is produced by various SST-secreting cells throughout the body and acts as a neurotransmitter or paracrine/autocrine regulator in response to ions, nutrients, peptides hormones and neurotransmitters. SST is also widely distributed in the periphery to regulate the inflammatory and immune cells in response to hormones, growth factors, cytokines and other secretive molecules. SST peptides are considered the most important physiologic regulator of the islet cell, gastrointestinal cell and immune cell functions, and the importance of SST production levels has been implicated in several diseases including diabetes. The expression of SST receptors has also been found in T lymphocytes and primary immunologic organs. Interaction of SST and its receptors is also involved in T-cell proliferation and thymocyte selection. SSTR gene-ablated mice developed diabetes with morphologic, physiologic and immunologic alterations in the endocrine pancreas. Increased levels of mononuclear cell infiltration of the islets are associated with the increased levels of antigen-presenting cells located in the islets and peripancreatic lymph nodes. Increased levels of SST were also found in antigen-presenting cells and are associated with a significant increase of CD8 expression levels on CD4(+)/CD8(+) immature thymocytes. These findings highlight the crucial role of this neuroendocrine peptide and its receptors in regulating autoimmune functions.

show abstract

Somatostatin receptors in the haematopoietic system

Cited by 31 publications

References 128 publications

Activation of somatostatin receptors attenuates pulmonary fibrosis

Activation of somatostatin receptors attenuates pulmonary fibrosis

The role of cortistatin in the human immune system

Somatostatin receptors and autoimmune‐mediated diabetes

Contact Info

Product

Resources

About