Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats

Sugimoto, Arisa; Tsuchida, Hitomi; Ieda, Nahoko; Ikegami, Kana; Inoue, N.; Uenoyama, Yoshihisa; Tsukamura, Hiroko

doi:10.1210/en.2018-00882

Cited by 15 publications

(16 citation statements)

References 78 publications

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“…In other vertebrates, SST was mainly found to regulate the pulsatile secretion of LH; in the ewe, ICV infusion of SST abolished the pulsatile secretion of LH and dramatically decreased its plasma levels [ 87 ]. In a lactating rat, SST signaling was shown to mediate the suckling-induced suppression of pulsatile LH secretion, while central injection of SST antagonist caused a significant increase in pulsatile LH release [ 88 ]. Expression of different SST receptor types on LH and FSH cells demonstrates sexual dimorphism in the regulation of SST on GtHs.…”

Section: Resultsmentioning

confidence: 99%

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

Hollander-Cohen

Golan

Levavi‐Sivan

2021

IJMS

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From mammals to fish, reproduction is driven by luteinizing hormone (LH) and follicle-stimulating hormone (FSH) temporally secreted from the pituitary gland. Teleost fish are an excellent model for addressing the unique regulation and function of each gonadotropin cell since, unlike mammals, they synthesize and secrete LH and FSH from distinct cells. Only very distant vertebrate classes (such as fish and birds) demonstrate the mono-hormonal strategy, suggesting a potential convergent evolution. Cell-specific transcriptome analysis of double-labeled transgenic tilapia expressing GFP and RFP in LH or FSH cells, respectively, yielded genes specifically enriched in each cell type, revealing differences in hormone regulation, receptor expression, cell signaling, and electrical properties. Each cell type expresses a unique GPCR signature that reveals the direct regulation of metabolic and homeostatic hormones. Comparing these novel transcriptomes to that of rat gonadotrophs revealed conserved genes that might specifically contribute to each gonadotropin activity in mammals, suggesting conserved mechanisms controlling the differential regulation of gonadotropins in vertebrates.

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Section: Resultsmentioning

confidence: 99%

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

Hollander-Cohen

Golan

Levavi‐Sivan

2021

IJMS

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“…On the other hand, it is unlikely that ARC Tac3 expression is affected by chronic undernutrition —albeit ARC Tac3 expression was reportedly suppressed by short-time fasting in the peripubertal period [39]—, because the number of Tac3 -expressing cells were comparable between the ad libitum -fed rats and food-restricted controls. Interestingly, ARC Kiss1 , Tac3 and Pdyn gene expression were also separately controlled during the lactational anestrus: our recent study [50] showed that Kiss1 expression was solely suppressed in ARC of lactating mother rats. The present results suggest that the chronic negative energy balance impairs KNDy neurons, namely the GnRH pulse generator, via suppression of Kiss1 and Pdyn expression, and the positive energetic cues trigger the completion of the functional GnRH pulse generator via increases in ARC Kiss1 and Pdyn expression.…”

Section: Discussionmentioning

confidence: 99%

Ad libitum feeding triggers puberty onset associated with increases in arcuate Kiss1 and Pdyn expression in growth-retarded rats

et al. 2019

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Increasing evidence shows that puberty onset is largely dependent on body weight rather than chronological age. To investigate the mechanism involved in the energetic control of puberty onset, the present study examined effects of chronic food restriction during the prepubertal period and the resumption of ad libitum feeding for 24 and 48 h on estrous cyclicity, Kiss1 (kisspeptin gene), Tac3 (neurokinin B gene) and Pdyn (dynorphin A gene) expression in the hypothalamus, luteinizing hormone (LH) secretion and follicular development in female rats. When animals weighed 75 g, they were subjected to a restricted feeding to retard growth to 70-80 g by 49 days of age. Then, animals were subjected to ad libitum feeding or remained food-restricted. The growth-retarded rats did not show puberty onset associated with suppression of both Kiss1 and Pdyn expression in the arcuate nucleus (ARC). 24-h ad libitum feeding increased tonic LH secretion and the number of Graafian and non-Graafian tertiary follicles with an increase in the numbers of ARC Kiss1-and Pdyn-expressing cells. 48-h ad libitum feeding induced the vaginal proestrus and a surge-like LH increase with an increase in Kiss1-expressing cells in the anteroventral periventricular nucleus (AVPV). These results suggest that the negative energy balance causes pubertal failure with suppression of ARC Kiss1 and Pdyn expression and then subsequent gonadotropin secretion and ovarian function, while the positive energetic cues trigger puberty onset via an increase in ARC Kiss1 and Pdyn expression and thus gonadotropin secretion and follicular development in female rats.

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“…Free-floating ISH for Rbbp7 was performed by using the rat hypothalamic sections collected from OVX + low E2 rats (n=3), as previously described [37,38]…”

Section: Rbbp7mentioning

confidence: 99%

“…gained from OVX + low E2 rats (n=3), as previously described [34,38]. Briefly, the Rbbp7-specific the AVPV region was punched out with 18-gauge stainless-steel tubing as previously described [40].…”

Section: Analysis Of Co-localization Of Rbbp7 and Kiss1 Expression Inmentioning

confidence: 99%

Retinoblastoma binding protein 7 is involved in Kiss1 mRNA upregulation in rodents

Horihata

Inoue

Uenoyama

et al. 2020

Journal of Reproduction and Development

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Somatostatin-Somatostatin Receptor 2 Signaling Mediates LH Pulse Suppression in Lactating Rats

Cited by 15 publications

References 78 publications

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary

<i>Ad libitum</i> feeding triggers puberty onset associated with increases in arcuate <i>Kiss1</i> and <i>Pdyn</i> expression in growth-retarded rats

Retinoblastoma binding protein 7 is involved in <i>Kiss1</i> mRNA upregulation in rodents

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