Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Pan, Chensheng; Peck, Kyung K.; Young, Robert J.; Holodny, Andrei I.

doi:10.3174/ajnr.a2952

Cited by 52 publications

(62 citation statements)

References 28 publications

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“…Our findings are also consistent with the few reports of acquired dysarthria in children who have had infarcts, whereby lesions mostly encompass the left putamen/internal capsule region, 15 through which this tract runs. 25 Finally, the association between left hemisphere speech-related tracts and speech function after TBI is in agreement with the association between left hemisphere infarct and acute dysarthria in adults.…”

supporting

confidence: 62%

Corticobulbar tract changes as predictors of dysarthria in childhood brain injury

et al. 2013

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Objectives: To identify corticobulbar tract changes that may predict chronic dysarthria in young people who have sustained a traumatic brain injury (TBI) in childhood using diffusion MRI tractography. Methods:We collected diffusion-weighted MRI data from 49 participants. We compared 17 young people (mean age 17 years, 10 months; on average 8 years postinjury) with chronic dysarthria who sustained a TBI in childhood (range 3-16 years) with 2 control groups matched for age and sex: 1 group of young people who sustained a traumatic injury but had no subsequent dysarthria (n 5 15), and 1 group of typically developing individuals (n 5 17). We performed tractography from spherical seed regions within the precentral gyrus white matter to track: 1) the hand-related corticospinal tract; 2) the dorsal corticobulbar tract, thought to correspond to the lips/larynx motor representation; and 3) the ventral corticobulbar tract, corresponding to the tongue representation.Results: Despite widespread white matter damage, radial (perpendicular) diffusivity within the left dorsal corticobulbar tract was the best predictor of the presence of dysarthria after TBI. Diffusion metrics in this tract also predicted speech and oromotor performance across the whole group of TBI participants, with additional significant contributions from ventral speech tract volume in the right hemisphere.Conclusion: An intact left dorsal corticobulbar tract seems crucial to the normal execution of speech long term after acquired injury. Examining the speech-related motor pathways using diffusion-weighted MRI tractography offers a promising prognostic tool for people with acquired, developmental, or degenerative neurologic conditions likely to affect speech. Recent advances in diffusion-weighted MRI analyses now allow the in vivo reconstruction of white matter pathways in the human brain using tractography.1 Although speech is vulnerable to numerous neurologic conditions, the association between speech disorders and integrity of the corticobulbar tracts is rarely examined. Traumatic brain injury (TBI) is a major cause of death and disability in children 2,3 and can have devastating consequences on a wide range of cognitive domains. 4 Focal as well as diffuse brain changes have been observed after TBI, including long-term white matter alterations 5,6 that can be now be revealed using diffusion-weighted imaging (DWI).7-11 Among children with moderate and severe TBI, approximately 20% may have chronic dysarthria, 12 which can affect speech across articulation, respiration, phonation, prosody, and resonance. Given the potential for functional reorganization seen in the immature brain, 6,13,14 studies in the chronic stage are crucial to unravel the neural basis of those deficits that do persist long term after TBI in childhood. Because a recent review indicated that damage along the corticobulbar/corticospinal tracts was a common feature in children with dysarthria, 15 we used tractography to test the

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confidence: 62%

Corticobulbar tract changes as predictors of dysarthria in childhood brain injury

et al. 2013

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“…Recent studies have reported on methods for identification and reconstruction of the CBT in the human brain, using DTT [11,13,20]. Two studies demonstrated the anatomical location of the CBT in the internal capsule [13,20]. However, no study has reported on the anatomical location of the corona radiata (CR), an area known for high rate stroke and traumatic brain injury, as well as poor motor outcome [4,10,15].…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The anatomical location of the corticobulbar tract at the corona radiata in the human brain: Diffusion tensor tractography study

Jang

Seo

2015

Neuroscience Letters

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“…Progressive signal changes at the level of the pons and PLIC were observed in the present patient, suggesting a slow degenerative process involving the CSTs. Interestingly, the FA values were more reduced in the posterior part of the PLIC where the foot pathways are usually located [Pan et al 2012], thus explaining the lower extremity-predominant spasticity.…”

Section: Discussionmentioning

confidence: 99%

A novel homozygous MCOLN1 double mutant allele leading to TRP channel domain ablation underlies Mucolipidosis IV in an Italian Child

et al. 2014

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Mucolipidosis type IV (MLIV) is a very rare disorder of late endosome/lysosome transport, characterized by neurodevelopmental abnormalities and progressive visual impairment owing to corneal clouding and retinal dystrophy. Greater than 70 % of MLIV patients are of Ashkenazi Jewish ancestry. Here we report a novel MCOLN1double mutant allele [c.395_397delCTG;c.468_474dupTTGGACC] which introduces a premature stop codon [p.Ala132del; p.Asn159LeufsX27] leading to almost complete abrogation of the region coding mucolipin-1, a member of the transient receptor potential (TRP) cation channel family. The genomic lesion was identified in homozygous state, in a non-Jewish Italian MLIV patient, who also presented abnormal serum gastrin levels. Conventional and advanced MRI sequences, including diffusion tensor imaging and tractography, were used for the assessment of white matter involvement in the patient.

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Somatotopic Organization of Motor Pathways in the Internal Capsule: A Probabilistic Diffusion Tractography Study

Abstract: BACKGROUND AND PURPOSE:The location of the motor pathways in the PLIC remains controversial. In the current study, we trace the fibers from the tongue, face, hand, and foot motor cortices by using probabilistic diffusion tractography and define their somatotopic organization in the PLIC.

Cited by 52 publications

References 28 publications

Corticobulbar tract changes as predictors of dysarthria in childhood brain injury

Corticobulbar tract changes as predictors of dysarthria in childhood brain injury

The anatomical location of the corticobulbar tract at the corona radiata in the human brain: Diffusion tensor tractography study

A novel homozygous MCOLN1 double mutant allele leading to TRP channel domain ablation underlies Mucolipidosis IV in an Italian Child

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