Somatotopic Organization of Primary Afferent Perikarya of the Guinea-pig Extraocular Muscles in the Trigeminal Ganglion: a Post-mortem DiI-tracing Study

Aigner, Martin; Lukas, Julius; Denk, Michaela; Ziya-Ghazvini, Farzad; Kaider, Alexandra; Mayr, Robert

doi:10.1006/exer.1999.0828

Cited by 13 publications

(4 citation statements)

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“…Comparable to rabbit EOMs, in EOMs of guinea pig muscle spindles and Golgi tendon organs (Maier et al, 1974) are absent. Post-mortem tracing of the oculomotor nerve in guinea pig reveal labelling of primary sensory perikarya in the ipsilateral trigeminal ganglion suggesting the existence of proprioceptors in the EOMs of this species (Aigner et al, , 2000.…”

Section: Discussionmentioning

confidence: 99%

Presence and Structure of Innervated Myotendinous Cylinders in Rabbit Extraocular Muscle

Blumer

Wasicky

Hötzenecker

et al. 2001

Experimental Eye Research

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Section: Discussionmentioning

confidence: 99%

Presence and Structure of Innervated Myotendinous Cylinders in Rabbit Extraocular Muscle

Blumer

Wasicky

Hötzenecker

et al. 2001

Experimental Eye Research

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“…The trigeminal ganglion is similar to the dorsal root ganglion in the spinal somatosensory system in terms of markers associated with nociception and nociception-related receptors. 1,5,13,60,77 From the ganglion, a single sensory root emerges and enters the central nervous system (CNS) at the level of the pons—the root entry zone (REZ). Primary afferent fibres terminate in the principal sensory nucleus (or main sensory nucleus [MSN]) and the spinal trigeminal nucleus (STN).…”

Section: Trigeminal Sensory Pathwaysmentioning

confidence: 99%

Trigeminal nerve and white matter brain abnormalities in chronic orofacial pain disorders

Moayedi

Hodaie

2019

PR9

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“…Modern studies in mammals using HRP transport from the EOM agree that there are somata of primary a¡erents from EOM, typical pseudo-unipolar cells, in the ipsilateral trigeminal ganglion; for example, lamb (Bortolami et al 1987;Manni et al 1966), cat (Porter & Spencer 1982) rat (Daunicht et al 1985), monkey (Porter et al 1983;Porter 1986), rabbit (Kashii et al 1989) and guinea pig (Aigner et al 2000). No tracer studies report the presence of putative somata in ME5 in ungulates (see Bortolami et al 1987) but, in the cat, Alvarado-Mallart et al (1975a,b) reported labelling of ME5 cells as well as of trigeminal ganglion cells.…”

Section: Point Outmentioning

confidence: 99%

The functions of the proprioceptors of the eye muscles

Donaldson

2000

Phil. Trans. R. Soc. Lond. B

173

142

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This article sets out to present a fairly comprehensive review of our knowledge about the functions of the receptors that have been found in the extraocular muscles--the six muscles that move each eye of vertebrates in its orbit--of all the animals in which they have been sought, including Man. Since their discovery at the beginning of the 20th century these receptors have, at various times, been credited with important roles in the control of eye movement and the construction of extrapersonal space and have also been denied any function whatsoever. Experiments intended to study the actions of eye muscle receptors and, even more so, opinions (and indeed polemic) derived from these observations have been influenced by the changing fashions and beliefs about the more general question of how limb position and movement is detected by the brain and which signals contribute to those aspects of this that are perceived (kinaesthesis). But the conclusions drawn from studies on the eye have also influenced beliefs about the mechanisms of kinaesthesis and, arguably, this influence has been even larger than that in the converse direction. Experimental evidence accumulated over rather more than a century is set out and discussed. It supports the view that, at the beginning of the 21st century, there are excellent grounds for believing that the receptors in the extraocular muscles are indeed proprioceptors, that is to say that the signals that they send into the brain are used to provide information about the position and movement of the eye in the orbit. It seems that this information is important in the control of eye movements of at least some types, and in the determination by the brain of the direction of gaze and the relationship of the organism to its environment. In addition, signals from these receptors in the eye muscles are seen to be necessary for the development of normal mechanisms of visual analysis in the mammalian visual cortex and for both the development and maintenance of normal visuomotor behaviour. Man is among those vertebrates to whose brains eye muscle proprioceptive signals provide information apparently used in normal sensorimotor functions; these include various aspects of perception, and of the control of eye movement. It is possible that abnormalities of the eye muscle proprioceptors and their signals may play a part in the genesis of some types of human squint (strabismus); conversely studies of patients with squint in the course of their surgical or pharmacological treatment have yielded much interesting evidence about the central actions of the proprioceptive signals from the extraocular muscles. The results of experiments on the eye have played a large part in the historical controversy, now in at least its third century, about the origin of signals that inform the brain about movement of parts of the body. Some of these results, and more of the interpretations of them, now need to be critically re-examined. The re-examination in the light of recent experiments that is presented here does not ...

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Somatotopic Organization of Primary Afferent Perikarya of the Guinea-pig Extraocular Muscles in the Trigeminal Ganglion: a Post-mortem DiI-tracing Study

Cited by 13 publications

References 50 publications

Presence and Structure of Innervated Myotendinous Cylinders in Rabbit Extraocular Muscle

Presence and Structure of Innervated Myotendinous Cylinders in Rabbit Extraocular Muscle

Trigeminal nerve and white matter brain abnormalities in chronic orofacial pain disorders

The functions of the proprioceptors of the eye muscles

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