Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex

Miyachi, Shigehiro; Lu, Xiaofeng; Imanishi, Michiko; Sawada, Kouji; Nambu, Atsushi

doi:10.1016/j.neures.2006.07.012

Cited by 84 publications

(79 citation statements)

References 34 publications

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“…This shift was significant across subjects in both left (caudate: z ϭ 7.88, P ϭ 0.0001; putamen: z ϭ 8.37, P Ͻ 0.0001) and right (caudate: z ϭ 7.51, P ϭ 0.0001; putamen: z ϭ 7.03, P ϭ 0.0002) hemispheres. Thus we are able to confirm the global ventral-dorsal somatotopic organization of corticostriatal projections and a more local rostral-caudal organization of inputs, both of which have been recently described in the nonhuman primate (Miyachi et al 2006).…”

Section: Somatotopy Of Motor Projectionssupporting

confidence: 85%

“…The only other a priori predicted topographic pattern in the corticostriatal pathways is a somatotopic organization of fibers from motor cortex (Miyachi et al 2006). Specifically, fibers projecting from lower extremity regions of the primary motor cortex, located in the dorsal aspects of the central sulcus, should terminate in dorsal and caudal areas of the striatum.…”

Section: Somatotopy Of Motor Projectionsmentioning

confidence: 99%

“…Projections from a single cortical area will diverge to a fairly broad area of the striatum and be further subdivided into these smaller patched structures. Thus cortical information is topographically organized, but within this topography there is some divergence of information being conveyed (Eblen and Graybiel 1995;Flaherty and Graybiel 1991, 1994Miyachi et al 2006).…”

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confidence: 99%

“…Specifically, we wanted to determine whether the global rostralcaudal continuum seen across cortical areas (for review see Haber 2003) persists more locally in projections from individual cortical areas (i.e., DLPFC; Badre and Frank 2012;Badre et al 2010) and to quantify the specificity of these representations. For example, how does this rostral-caudal organization interact with the dorsal-ventral somatotopic organization of projections from the motor cortex (Miyachi et al 2006)?…”

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confidence: 99%

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Microstructural organizational patterns in the human corticostriatal system

Verstynen

Badre

Jarbo

et al. 2012

Journal of Neurophysiology

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The axons that project into the striatum are known to segregate according to macroscopic cortical systems; however, the within-region organization of these fibers has yet to be described in humans. We used in vivo fiber tractography, in neurologically healthy adults, to map white matter bundles that originate in different neocortical areas, navigate complex fiber crossings, and project into the striatum. As expected, these fibers were generally segregated according to cortical origin. Within a subset of pathways, a patched pattern of inputs was observed, consistent with previous ex vivo histological studies. In projections from the prefrontal cortex, we detected a topography in which fibers from rostral prefrontal areas projected mostly to rostral parts of the striatum and vice versa for inputs originating in caudal cortical areas. Importantly, within this prefrontal system there was also an asymmetry in the subset of divergent projections, with more fibers projecting in a posterior direction than anterior. This asymmetry of information projecting into the basal ganglia was predicted by previous network-level computational models. A rostral-caudal topography was also present at the local level in otherwise somatotopically organized fibers projecting from the motor cortex. This provides clear evidence that the longitudinal organization of input fields, observed at the macroscopic level across cortical systems, is also found at the microstructural scale at which information is segregated as it enters the human basal ganglia. basal ganglia; diffusion imaging; topographic ALTHOUGH TYPICALLY THOUGHT OF as a motor control area, the basal ganglia processes information from a variety of cortical and subcortical regions (Alexander et al. 1986;Draganski et al.

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Section: Somatotopy Of Motor Projectionssupporting

confidence: 85%

Section: Somatotopy Of Motor Projectionsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Microstructural organizational patterns in the human corticostriatal system

Verstynen

Badre

Jarbo

et al. 2012

Journal of Neurophysiology

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“…Interestingly, the electrophysiological data indicate that this tonic activity affects forelimb but not vibrissa motor representations. The main reason of this difference may be the nature of vibrissa and forelimb motor systems which involve different cortico-basal ganglia motor circuits (Hoover et al, 2003;Miyachi et al, 2006).…”

Section: Neurobiological Substrates Of N/ofq Actionsmentioning

confidence: 99%

Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata

Marti

Viaro

Guerrini

et al. 2008

Neuropsychopharmacol

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This study was set to investigate whether motor effects of nociceptin/orphanin FQ (N/OFQ) can be related to changes in primary motor cortex output. N/OFQ injected i.c.v. biphasically modulated motor performance, low doses being facilitating and higher ones inhibitory. These effects were counteracted by the N/OFQ receptor antagonist [Nphe 1 Arg 14 ,Lys 15 ]N/OFQ-NH 2 (UFP-101) confirming the specificity of N/OFQ action. However, UFP-101 alone facilitated motor performance, suggesting that endogenous N/OFQ inhibits motor function. N/OFQ and UFP-101 injected into the substantia nigra reticulata but not motor cortex replicated these effects, suggesting motor responses were mediated by subcortical circuits involving the basal ganglia. Intracortical microstimulation technique showed that i.c.v. N/OFQ also biphasically modulated motor cortex excitability and movement representation. Low N/OFQ doses caused a leftward shift of threshold distribution curve in the forelimb area without affecting the number of effective sites. Conversely, high N/OFQ doses increased unresponsive and reduced excitable (movement) sites in vibrissa but not forelimb area. However, increased threshold currents and rightward shift of threshold distribution curve were observed in both areas, suggesting an overall inhibitory effect on cortical motor output. UFP-101 alone evoked effects similar to low N/OFQ doses, suggesting tonic inhibitory control over forelimb movement by endogenous N/OFQ. As shown in behavioral experiments, these effects were replicated by intranigral, but not intracortical, N/OFQ or UFP-101 injections. We conclude that N/OFQ receptors located in the substantia nigra reticulata mediate N/OFQ biphasic control over motor behavior, possibly through changes of primary motor cortex output.

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The basal ganglia in Parkinson's disease: Current concepts and unexplained observations

et al. 2009

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The pathophysiology of Parkinson's disease is reviewed in light of recent advances in the understanding of the functional organization of the basal ganglia (BG). Current emphasis is placed on the parallel interactions between corticostriatal and corticosubthalamic afferents on the one hand, and internal feedback circuits modulating BG output through the globus pallidus pars interna and substantia nigra pars reticulata on the other. In the normal BG network, the globus pallidus pars externa emerges as a main regulatory station of output activity. In the parkinsonian state, dopamine depletion shifts the BG toward inhibiting cortically generated movements by increasing the gain in the globus pallidus pars externa-subthalamic nucleus-globus pallidus pars interna network and reducing activity in "direct" cortico-putaminal-globus pallidus pars interna projections. Standard pharmacological treatments do not mimic the normal physiology of the dopaminergic system and, therefore, fail to restore a functional balance between corticostriatal afferents in the so-called direct and indirect pathways, leading to the development of motor complications. This review emphasizes the concept that the BG can no longer be understood as a "go-through" station in the control of movement, behavior, and emotions. The growing understanding of the complexity of the normal BG and the changes induced by DA depletion should guide the development of more efficacious therapies for Parkinson's disease.

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Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex

Cited by 84 publications

References 34 publications

Microstructural organizational patterns in the human corticostriatal system

Microstructural organizational patterns in the human corticostriatal system

Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata

The basal ganglia in Parkinson's disease: Current concepts and unexplained observations

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