Somatotrope Heterogeneity and Its Involvement in Growth Hormone (GH) Regulation

Castaño, Justo P; Ramı́rez, José Luis; Garrido‐Gracia, José C.; Gracia‐Navarro, Francisco

doi:10.1007/978-1-4612-1546-2_17

Cited by 1 publication

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the exact significance of heterogeneous gene expression and chromatin accessibility within somatotrophs remains unclear, these molecular signatures may represent distinct functional cell states that allow dynamic neuroendocrine responses to homeostatic stimuli. For instance, growth hormone secretion by the somatotroph cells is a dynamic process involving both pulsatile patterns over a minute timescale and chronic fluctuations associated with growth or aging [26]. Generating distinct cell subpopulations with unique growth hormone release patterns may be one of the possible mechanisms behind secretory plasticity.…”

Section: Normal Somatotroph Transcriptional Pathways During and After...mentioning

confidence: 99%

Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells

Osorio

Jung

et al. 2022

Cancers

View full text Add to dashboard Cite

The pituitary gland is one of the most cellularly diverse regions of the brain. Recent advancements in transcriptomic biology, such as single-cell RNA sequencing, bring an unprecedented glimpse into the molecular composition of the pituitary, both in its normal physiological state and in disease. Deciphering the normal pituitary transcriptomic signatures provides a better insight into the ontological origin and development of five types of endocrine cells, a process involving complex cascades of transcription factors that are still being established. In parallel with these observations about normal pituitary development, recent transcriptomic findings on pituitary neuroendocrine tumors (PitNETs) demonstrate both preservations and changes in transcription factor expression patterns compared to those seen during gland development. Furthermore, recent studies also identify differentially expressed genes that drive various tumor behaviors, including hormone hypersecretion and tumor aggression. Understanding the comprehensive multiomic profiles of PitNETs is essential in developing molecular profile-based therapies for PitNETs not curable with current treatment modalities and could eventually help align PitNETs with the breakthroughs being made in applying precision medicine to other tumors.

show abstract

Section: Normal Somatotroph Transcriptional Pathways During and After...mentioning

confidence: 99%