Somatotropin and Prolactin Enhance Respiratory Burst Activity of Macrophagesa

Edwards, Carl K.; Schepper, Jeanette M.; Yunger, Libby M.; Kelley, Keith W.

doi:10.1111/j.1749-6632.1988.tb27216.x

Cited by 13 publications

(3 citation statements)

References 4 publications

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“…CF neutrophils have greater levels of NADPH oxidase activity than control cells. 45 Edwards et al 123 have provided evidence that PRL augments the production of O 2 by mononuclear phagocytes in vitro by testing the NADPH oxidase system in porcine mononuclear phagocytes with PRL. PRL antiserum blocked more than 90% of the O 2 induced by the hormone.…”

Section: Abnormalities Of the Cellular Immune Systemmentioning

confidence: 99%

Cystic Fibrosis: Studies on the Role of Prolactin in a Gene Disorder

Robertson¹

1992

Semin Reprod Med

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Section: Abnormalities Of the Cellular Immune Systemmentioning

confidence: 99%

Cystic Fibrosis: Studies on the Role of Prolactin in a Gene Disorder

Robertson¹

1992

Semin Reprod Med

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“…Because CNS-infected cows appear to produce more milk than noninfected cows (Compton et al, 2007;Schukken et al, 2009;Piepers et al, 2010), we investigated the milk yield and the response of milk PRL after CNS challenge in clinically healthy dairy heifers. A plethora of evidence implicates PRL as an immunomodulating factor (Edwards et al, 1987;Krishnan et al, 2003;Brand et al, 2004;Boutet et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…The ubiquitous PRL receptor belongs to the class I cytokine receptor superfamily, which also includes the receptors of several interleukins and hematopoietic growth factors (Bazan, 1989(Bazan, , 1990. The hormone promotes the activity of macrophages (Edwards et al, 1987), inhibits the apoptosis of T-lymphocytes caused by glucocorticoids (Krishnan et al, 2003), and stimulates the production of tumor necrosis factor-α and IL-12 (Brand et al, 2004). Considering the immunomodulatory actions of PRL, several studies have focused on its potential involvement in bovine mastitis.…”

Section: Introductionmentioning

confidence: 99%

Milk prolactin response and quarter milk yield after experimental infection with coagulase-negative staphylococci in dairy heifers

Piccart

Piepers

Verbeke

et al. 2015

Journal of Dairy Science

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Coagulase-negative staphylococci (CNS) are the most common bacteria involved in subclinical mastitis in dairy cows. Remarkably, CNS-infected dairy heifers produce more milk than uninfected heifers. Because the lactation hormone prolactin (PRL) is also involved in mammary gland immunity, we investigated the milk PRL response and the mammary quarter milk yield following experimental CNS challenge. Eight healthy Holstein-Friesian heifers in mid-lactation were experimentally infected using a split-udder design with 3 different CNS strains: one Staphylococcus fleurettii (from sawdust bedding) and 2 Staphylococcus chromogenes strains (one isolate from a teat apex, the other isolate from a chronic intramammary infection). Three mammary quarters per heifer were simultaneously inoculated with 1.0×10(6) cfu, whereas the remaining mammary quarter was infused with sterile phosphate-buffered saline, serving as a control. An existing radioimmunoassay was modified, validated, and used to measure PRL frozen-thawed milk at various time points until 78h after challenge. The mean milk PRL level tended to be higher in the CNS-challenged mammary quarters compared with the control mammary quarters (7.56 and 6.85ng/mL, respectively). The increase in PRL over time was significantly greater in the CNS-challenged mammary quarters than in the control mammary quarters. However, no difference was found in the PRL response when comparing each individual CNS strain with the control mammary quarters. The mean mammary quarter milk yield tended to be lower in the CNS-infected mammary quarters than in the control mammary quarters (1.73 and 1.98kg per milking, respectively). The greatest milk loss occurred in the mammary quarters challenged with the intramammary strain of S. chromogenes. Future observational studies are needed to elucidate the relation between PRL, the milk yield, and the inflammatory condition, or infection status, of the mammary gland.

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In vivo activation of macrophages by prolactin from young and aging mice

Chen

Johnson

1993

International Journal of Immunopharmacology

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Somatotropin and Prolactin Enhance Respiratory Burst Activity of Macrophagesa

Cited by 13 publications

References 4 publications

Cystic Fibrosis: Studies on the Role of Prolactin in a Gene Disorder

Cystic Fibrosis: Studies on the Role of Prolactin in a Gene Disorder

Milk prolactin response and quarter milk yield after experimental infection with coagulase-negative staphylococci in dairy heifers

In vivo activation of macrophages by prolactin from young and aging mice

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