Somatotropin Penetration Testing from Formulations Applied Topically to the Skin

Siemiradzka, Wioletta; Franczyk, Agata; Bułaś, Lucyna; Dolińska, Barbara

doi:10.3390/app13042588

Cited by 2 publications

(1 citation statement)

References 50 publications

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“…The prepared hydrogel formulations were inspected visually for their color, appearance, uniformity and consistency, stickiness, greasiness and greasing, and adhesion [59]. The method of performing the tests was previously described by Siemiradzka et al [60].…”

Section: Visual and Sensory Inspection Of Prepared Formulationsmentioning

confidence: 99%

Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

2023

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Topical drug delivery in skin diseases provides a non-invasive, direct application of treatments to the affected area and avoids systemic toxicity. Quercetin is a natural polyphenol with documented activity to alleviate the symptoms of many skin diseases. The objective of this study was to prepare and assess the physicochemical properties of hydrogels made of sodium alginate (SA) and cellulose derivatives (methyl cellulose (MC) and carboxymethyl cellulose (CMC)), containing different concentrations of quercetin (0.4 and 0.7%). The physicochemical evaluation of the obtained hydrogels included organoleptic evaluation, texture analysis, spreadability, rheological properties, pH, and stability. Among the prepared formulations, MC-based gels had the highest viscosity, adhesiveness, cohesiveness, and stickiness. The results of this study indicate that MC-based hydrogels were superior to CMC- or SA-based gels in their ability to effectively deliver quercetin to the porcine skin ex vivo. The amount of quercetin retained in the skin after application of MC-based preparations containing higher concentrations of quercetin was 2.04-fold higher for CMC-based hydrogels and 2.6-fold higher for SA-based hydrogels.

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Section: Visual and Sensory Inspection Of Prepared Formulationsmentioning

confidence: 99%

Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

2023

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Study of the Effect of Phosvitin as a Potential Carrier on the Permeation Process of Somatotropin (STH) and Corticotropin (ACTH) from Biodegradable Polymers Used as Vehicles for STH and ACTH in Semi-Solid Formulations for Skin Application

Siemiradzka,

Kędzierska,

Rynk

et al. 2024

Polymers

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Phosvitin shows chelating abilities, an affinity for ACTH (corticotropin), growth factors, antioxidant properties, and acidic nature. An attempt was made to use this protein in hydrogels as a transporter of other protein substances: somatotropin (STH) and (ACTH). The aim of the study was to evaluate the effect of phosvitin on the permeation of ACTH and STH from semi-solid forms of the drug applied to the skin. Four hydrogel substrates were prepared using natural polymers: sodium alginate, methylcellulose, and starch. Based on the evaluation of physicochemical parameters, the hydrogel with the most favorable properties was selected and loaded with the active substances STH and ACTH, followed by the addition of phosvitin. A study of the permeation of STH and ACTH through the artificial cellulose membrane and through porcine skin was carried out without and with the addition of phosvitin. The effect of protein substances on rheological and textural parameters was studied. The evaluation of physicochemical parameters showed a favorable effect of STH and Phosvitin on the stability of the hydrogel with 4% methylcellulose and no effect of ACTH. All prepared formulations showed a reaction close to the natural pH of human skin. In the porcine skin permeation study, the addition of Phosvitin to the hydrogel with STH caused a slight increase in the amount of STH permeated and an increase in the time for STH to permeate porcine skin by 30 min. Phosvitin caused an increase in the amount of ACTH permeated through porcine skin almost twofold. Phosvitin may prove to be a promising permeation promoter for model protein-peptide substances when applied to the skin surface.

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Somatotropin Penetration Testing from Formulations Applied Topically to the Skin

Cited by 2 publications

References 50 publications

Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

Formulation and Evaluation of Hydrogels Based on Sodium Alginate and Cellulose Derivatives with Quercetin for Topical Application

Study of the Effect of Phosvitin as a Potential Carrier on the Permeation Process of Somatotropin (STH) and Corticotropin (ACTH) from Biodegradable Polymers Used as Vehicles for STH and ACTH in Semi-Solid Formulations for Skin Application

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