Somatotropin supplementation decreases feed intake in crossbred dairy goats during the early phase of lactation

Thammacharoen, Sumpun; Nguyen, Thanh Hai; Suthikai, W.; Chanchai, W.; Chanpongsang, S.; Chaiyabutr, Narongsak

doi:10.1016/j.smallrumres.2014.07.005

Cited by 9 publications

(15 citation statements)

References 35 publications

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“…Negative effects of HTa on ruminal functions, such as lower ruminal pH, microbial activities and fermentation characteristics, have been well reported [2,3]. In dairy goats, leptin as an adiposity hormone has been shown to be involved in satiation [4]. Plasma leptin concentration increased in heat-stressed dairy goats [5].…”

Section: Introductionmentioning

confidence: 97%

Effects of dietary cation and anion difference on eating, ruminal function and plasma leptin in goats under tropical condition

Nguyen

Chanpongsang

Chaiyabutr

et al. 2020

Asian-Australas J Anim Sci

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Objective: This study was carried out to determine the effects of elevated dietary cation and anion difference (DCAD) on dry matter intake (DMI) and ruminal fermentation pattern in lactating dairy goats under tropical conditions.Methods: Ten dairy goats were divided into two groups of five animals each. The groups received diets at different DCAD levels, either a control diet (22.81 mEq/100 g dry matter [DM], DCAD-23) or a DCAD-39 diet (39.08 mEq/100 g DM, DCAD-39). After parturition, DMI and water intake were recorded daily. Ruminal fluid and urine were collected, and nutrient digestibility measurements were carried out at 8th weeks postpartum (PP-8). Blood samples were collected at PP-4 and PP-8 to measure plasma leptin.Results: Dry matter intake/body weight (DMI/BW) at PP-8 of the animals fed the DCAD-39 diet was significantly higher than those fed with DCAD-23 diet (p<0.05). Animals fed with DCAD-39 consumed more water than those fed DCAD-23 over 24 h, particularly at night (p<0.05). Ruminal pH, acetate concentration, and urinary allantoin excretion increased with the DCAD-39 diet, whereas ruminal butyrate concentration was lower with the DCAD-39 diet. On the other hand, other ruminal parameters, such as total volatile fatty acid concentration, propionate molar proportion and acetate/propionate average ratio, were not affected by increased DCAD supplementation. Apparent digestibility was improved by increased DCAD supplementation. Plasma leptin concentration was higher with DCAD supplementation.Conclusion: When feeding goats with DCAD-39 under tropical conditions, an increase in DMI was associated with improved apparent digestibility of nutrients, ruminal fermentation and microbial protein synthesis. An increase in plasma leptin concentration could not explain the effect of high DCAD on DMI.

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Section: Introductionmentioning

confidence: 97%

Effects of dietary cation and anion difference on eating, ruminal function and plasma leptin in goats under tropical condition

Nguyen

Chanpongsang

Chaiyabutr

et al. 2020

Asian-Australas J Anim Sci

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“…Several investigations have reported inconsistent observations about the action of bST treatment in dairy cows and goats kept at a high environmental temperature. It was reported that dairy cows and goats treated with bST under short-term exposure to hot environmental conditions increased their milk production and the hot environmental conditions did not reduce these bST effects [2,5]. Other investigators reported that a high ambient heat load reduced the response to bST treatment and conferred low milk yields [6], while heat-stressed cows had an elevated rectal temperature (RT) and respiratory rate (RR), which was exacerbated in cows receiving bST treatment [7].…”

Section: Introductionmentioning

confidence: 99%

Exogenous bovine somatotropin and mist-fan cooling synergistically promote the intramammary glucose transport for lactose synthesis in crossbred Holstein cows in the tropics

et al. 2021

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Background and Aim: Milk synthesis by the mammary gland is negatively influenced in part by high ambient temperature (AT). This study aimed to clarify the pathway of intramammary glucose utilization involved in mediating lactose synthesis during treatment with somatotropin under housing with misters and fans. Materials and Methods: A single subcutaneous injection of 500 mg of recombinant bovine somatotropin (rbST) was administered 3 times once every 14 days to 87.5% crossbred Holstein cattle in early-/mid-/late lactation, under housing in a normal shaded barn and in a shaded barn with a mist-fan cooling system. Results: The milk yields of the cooled cows tended to increase compared with those of uncooled cows and exhibited more potentiated effects in response to rbST treatment, coinciding with increases in mammary plasma flow and glucose uptake, but not in the mammary extraction of glucose. Treatment with rbST in the cooled cows resulted in a greater increase in the milk glucose concentration and a greater decrease in the milk glucose-6-phosphate concentration at all stages of lactation. Conclusion: rbST treatment exerted its galactopoietic action more by local intramammary factors than by other extramammary factors at a low AT and the synergistic effect between rbST treatment and low AT increased the availability of intramammary glucose transport in activating the process of lactose synthesis.

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“…Finally, the metabolic effects of GH are closely related to and influenced by insulin and leptin [21]. The latter argument appeared to be the major cause of the discrepancy in the short-term GH treatment on plasma leptin [11][12][13][14][15]. To study whether fat mass influenced the effect of GH on plasma leptin, the current experiments investigated the short-term effects of GH treatment on 2 different amounts of adipose tissue mass from control and obese rats.…”

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confidence: 97%

“…glucose, and FFA in the diurnal patterns of plasma leptin [3,4,[8][9][10]. In addition to these well-known effects of insulin on plasma leptin, growth hormone (GH) has also been demonstrated to influence plasma leptin [11][12][13][14][15]. With longterm GH treatment, lower plasma leptin has been demonstrated in accordance with decreased fat mass [16,17].…”

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confidence: 99%

“…First, obesity is associated with attenuated plasma GH, in which GH has long been considered as hormonal treatment in obesity and metabolic syndrome [18][19][20]. Second, short-term GH treatment decreased food intake (FI) in laboratory rodents and goats [14,15], which may associate with elevated plasma leptin in this period. Finally, the metabolic effects of GH are closely related to and influenced by insulin and leptin [21].…”

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confidence: 99%

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Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats

Likitnukul

Kalandakanond-Thongsong

Thammacharoen

2018

Asian Biomedicine

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Background Plasma leptin is regulated by several factors, including growth hormone (GH), which influences the pathophysiology of obesity. Objective To demonstrate the short-term effect of GH on plasma leptin levels in 3 conditions in vivo with the different amount of body fat mass. Methods Adult male Wistar rats were fed with standard chow or hypercaloric diet (HC). The HC rats were demonstrated as HC-feeding obese (HC-O) and HC-feeding resistant (HC-R) rats. Then, they were treated with GH or saline for 3 days. Basal plasma leptin levels were measured at 24 and 32 h. For meal-induced condition, all rats were fed for 2 hand plasma leptin was measured. Further 16-h fasting period, plasma leptin, insulin, and insulin sensitivity indexes were determined. Results The short-term GH treatment decreased basal plasma leptin at 32 h after the first GH injection in HC-O rats. However, GH treatment had no effect on meal-induced plasma leptin in all rats. Furthermore, GH treatment attenuated fasting effect on plasma leptin in control and HC-R rats. The insulin resistance (IR) induced by the short-term GH treatment was demonstrated by higher fasting plasma insulin and the increased homeostasis model of IR in HC-R rats. Conclusions The study demonstrates the important role of greater fat mass in HC-O rats, which results in decreased basal plasma leptin after short-term GH treatment. For meal-induced condition, GH had no effect on plasma leptin in all rats. Interestingly, GH could attenuate fasting effect on plasma leptin in rats that have lower fat mass.

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Somatotropin supplementation decreases feed intake in crossbred dairy goats during the early phase of lactation

Cited by 9 publications

References 35 publications

Effects of dietary cation and anion difference on eating, ruminal function and plasma leptin in goats under tropical condition

Effects of dietary cation and anion difference on eating, ruminal function and plasma leptin in goats under tropical condition

Exogenous bovine somatotropin and mist-fan cooling synergistically promote the intramammary glucose transport for lactose synthesis in crossbred Holstein cows in the tropics

Evidence of growth hormone effect on plasma leptin in diet-induced obesity and diet-resistant rats

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