Diabetes is a social health problem that is large with special attention in the community and among individuals. Nevertheless, the efforts to spread paradigm of health society to inputsocial determinant of health including analysis and contextual of social factors that are considered out of the scope of the health research is seldom conducted. As a result, the conceptualization of dynamic health inequality of diabetes is superficial. By using a holistic anthropologist lens has the potency to offer insight intothe character of socialdeterminer which is wider. The individual factor that is traditionally focused on the health of society and qualitative exploration structural, deeply local context, social environment, and culture, and their interaction and intersexuality, as the key factors, while considering how to reach alterations. The systematic study aims to describe that culture, ethnicity, and lifestyle have much impacton the patients of diabetes mellitus. The method of the systematic study is the article's investigations which are listed by PubMed with the keywords "culture, ethnic, lifestyle, and diabetes". Twenty-nine articles are got from the result of an investigation and after a selection has been done and got five articles to be analyzed furthermore. The result of the review of the literature study shows that culture, ethnicity, and lifestyle are able to influence the case of diabetes illness to the individual or group. On a certain ethnic group besides economic problem, the characteristic ofcertain body starts from size and shape of the body make someone can suffer from diabetes, in addition,the motoric activity of the body and physical activity can influence the case of diabetes.