2023
DOI: 10.1111/cbdd.14343
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Some 2‐[4‐(1H‐benzimidazol‐1‐yl) phenyl]‐1H‐benzimidazole derivatives overcome imatinib resistance by induction of apoptosis and reduction of P‐glycoprotein activity

Yalda Hekmatshoar,
Tulin Ozkan,
Mehmet Alp
et al.

Abstract: Imatinib (IMA) is a tyrosine kinase inhibitor (TKI) introduced for the chronic myeloid leukemia (CML) therapy. Emergence of IMA resistance leads to the relapse and failure in CML therapy. Benzimidazole is a heterocyclic organic compound which is widely investigated for the development of anticancer drugs. In this study, we aimed to explore the anticancer effects of some 2‐[4‐(1H‐benzimidazol‐1‐yl) phenyl]‐1H‐benzimidazole derivatives on K562S (IMA‐sensitive) and K562R (IMA‐resistant) cells. To analyze the cyto… Show more

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