Some 9‐Amino‐Acridine Derivatives Containing Silicon

Abstract

p-Tri-methylsilylphenethylamine and 1-p-trimethylsilyphenyl-1-amino4dimethyl-amino-butane were reacted with 9-chloroacridines to give the corresponding Nsubstituted 9-amino acridines, which inhibited the growth of several bacteria but not yeasts.

Alkoxy(alkyl)silylalkyl derivatives of nitrogen-containing heterocycles

“…N,N H -Bis(triethoxysilylalkyl)piperazines were obtained by heating triethoxy(chloroalkyl)silane with piperazine in a 2 : 1 molar ratio. 89 Heating of quinoline-2-and -4-carbonyl chlorides, 92 9-chloroacridine 96 and chloroquinolines 91,97 ± 99 with (3-aminopropyl)trialkylsilanes gives the corresponding 3-(trialkylsilyl)propylamino derivatives of these heterocycles.…”