An update is provided of an earlier review (Gruzelier, 1998) of the range of evidence for neurophysiological changes in frontal and lateralized functions with hypnosis, changes which have differentiated high from low hypnotically susceptible subjects, and which led to a working model and neuropsychological translation of the hypnotic induction process. New evidence is outlined from an fMRI/EEG study. This study also disclosed the importance of neural efficiency in left lateral frontal and anterior cingulate structures, and their connectivity, for distinguishing high from low hypnotic susceptibility both in hypnosis and in the everyday state. This amplifies earlier constructs such as cognitive flexibility. Though the focus will be largely on the alteration of connections with the anterior brain and its corresponding alterations of function, interhemispheric, posterior and subcortical connectivity is also considered. The practical implications for the interaction between the hypnotherapist and subject are considered, including stage hypnosis. Key words: EEG, fMRI, hypnosis, hypnotic susceptibility, neurophysiology, stage hypnosis
Neurocognitive changes with hypnosis
Selective inhibition, dissociation and disconnectionSince the time of Janet dissociation has been historically the dominating cognitive theory of hypnosis (Hilgard, 1965;Bowers, 1992). Now a range of evidence is showing that following instructions of hypnosis a different and unusual pattern of abilities and disabilities is brought into play in hypnotizable subjects compared with the pre-hypnosis state. These involve dissociations between cognitive processes, and disconnections between brain regions together with selective inhibition and enhancement of abilities and processes (Gruzelier, 1998;2004). The likening of hypnosis to an inhibitory process is enshrined in the term hypnosis, itself derived from Hypnos the god of sleep, and initially made popular by Pavlov's inhibitory concepts. Early electrophysiological studies found no evidence of sleep per se (Crawford and Gruzelier, 1992), nevertheless frontal inhibition may represent one dynamic of frontal involvement in hypnosis (e.g. Gruzelier, 1990;1998;Woody and Bowers, 1994;Woody and Sadler, 1998), and one which may be an alternative to disconnection, or be in parallel with it. The experimental evidence for changes in anterior brain activity will be considered in turn. Error detection and evaluation Neurophysiological fractionation of processes, to include possible inhibition, has been demonstrated between error detection processes and error evaluation processes and with the apparent inhibition or uncoupling of the latter, both of which are processes emanating from the anterior cingulate. These processes were measured with event-related potentials (ERPs) in a Stroop-like conflict task (Kaiser, Barker, Haenschel, Baldeweg and Gruzelier, 1997). The ERPs disclosed a dissociation not evident behaviourally. In the highly hypnotizable participants error detection rates decreased and reaction times (RT...