Some Air for Closure of the Patent Foramen Ovale

Meier, Bernhard

doi:10.1016/j.jcin.2012.02.008

Cited by 5 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite intra-cardiac rightto-left shunting is one of the causes of hypoxemia [3], relationship between anatomical shunt, and hypoxemia remains unclear [7][8][9]. PFO closure can improve patients' outcome and quality of life [10][11][12]. The 100% oxygen inhalation test or Hyperoxia Test (HT) has been proposed since early 1960' to quantify the shunt fraction regardless its mechanism [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Rest Hypoxemia: Is there a Place for the 100% Oxygen Test for Pathological Shunt Detection?

Bregeon

2020

BJSTR

View full text Add to dashboard Cite

Background:The Hyperoxia Test (HT) has been proposed to quantify the shunt fraction but it is often requested as a first-line diagnostic tool, without clear guidelines on its place in the strategy for diagnosing hypoxemia.Objectives: To question the contribution of HT in managing patients with hypoxemia, taking into account comparison with morphological examinations. Methods:We retrospectively went through on patient files referred to the Pulmonary Functional Test (PFT) laboratory from January 2016 to December 2019. Clinical, PFTs and echocardiographic data were collected.Results: 53 cases were analyzed, HT showed a shunt above 7.5 % (HT+ group) in 42 (79%). Most of patients had a preexisting pulmonary disease. Rest PaO 2 and DLCOc/VA significantly differed between HT-and HT+ Eighteen of the HT+ patients had morphological examinations, five had an anatomic abnormality. Estimated shunt fraction was negatively strongly correlated with rest PaO 2 and DLCOc/VA. When compared to a predicted exploration strategy based on shunt value and PFTs abnormalities, the actual exploration strategy showed good concordance in HT-patients and some discrepancies in HT+ ones, but most of the time, there was a clinical reason to explain why a HT+ patients was no further investigated with echocardiography. Conclusion:HT appeared as an easy-to-do diagnostic tool in hypoxemic patients that could help to rule out pathologic shunt and to screen those eligible for more complex specialized exploration.

show abstract