Some applications of the Grignard cross-coupling reaction in the industrial field

Highly active g-C3N4 as a solid base catalyst for knoevenagel condensation reaction under phase transfer conditions

“…Stilbenes and its derivatives are important intermediates in the agrochemical [34][35][36] polymer, 37,38 food 39 pharmaceutical industries [40][41][42] Moreover stilbene synthesis reported procedures suffer from long reaction time, high metal content, high base usage, non recyclable and accidental prone at higher temperature. 43,[44][45][46] On the other hand phase transfer catalysis (PTC) offer, efficient, mild and environment friendly reaction conditions, with the replacement of hazardous and sensitive bases or other chemicals. [47][48][49][50][51][52] In the present research study we combined the solid base g-C 3 N 4 with a phase transfer agent to catalyze the Knovenagel condensation under ambient conditions, to the best of our knowledge this combination is novel and was not reported previously.…”

A Highly Enantioselective Alkene Methoxycarbonylation Enables a Concise Synthesis of (S)‐Flurbiprofen

“…We felt a preferable synthesis might make use of a vinyl electrophile and a more stable aromatic Grignard reagent . Indeed, large scale syntheses of vinyl arenes from vinyl chloride have been carried out before . We found that vinyl tosylate, readily available by the decomposition of tetrahydrofuran, was an easier to handle vinyl electrophile than gaseous but cheap vinyl chloride/bromide, and could be cross‐coupled with (2‐fluoro‐1,1′‐biphenyl‐4‐yl)magnesium bromide with good efficiency in the presence of 1 mol‐% ( S )‐1 mo or ( R )‐2 mo [Scheme (ii) and Table ].…”

Copper Catalyzed C−H Activation

“…Coupling of functionalized hydrocarbons is carried out normally by using stoichiometric amounts of organometallic reagents, Grignard and organo‐lithium reagents or the transition metal catalysts. Commercially important products were made due to the continued progress in this field over the years. Prefunctionalization of starting materials adds steps which is detrimental for atom‐economical processes.…”