Some aromatic compounds from the marine sponge Plakortis halichondrioides

Total Synthesis of (±)-Gracilioether F

“…Ever since the first isolation of the initial secondary metabolite, plakortin, by Faulkner in 1978 from sponges of the genus Plakortis , many new family members of the Plakortin polyketides have been continuously characterized and reported. These compounds are characterized with rich chemical diversity and potential biological activities.…”

Marine natural products: metabolites of marine invertebrates

“…One of these specimens did not contain any cyclic peroxide but instead was the source of seven aromatic compounds (32)- (38). 45 The two major metabolites, which are the Mactone (32) and the y-lactone (33), are related through a cyclopropylcarbinol-homoallylic alcohol rearrangement and the ti-lactone (32) is related to a minor metabolite, the P-hydroxy-ester (39, by a similar rearrangement. The Phydroxy-acid corresponding to (35) is probably the biosynthetic precursor of the y-lactone (32) and, through decarboxylation, of the two hydrocarbons (37) and (38).…”

“…A specimen of the same sponge that had been lyophilized and extracted with dichloromethane contained the same methyl ester (41) together with a hydrolysis product (42) and two seemingly unrelated peroxides (43) and (44) that incorporate an additional propionate unit. Two unstable cyclic peroxides, the y-lactone (45) and the acid (46), together with the hydrocarbon (47), were obtained in rather low yield from an undescribed species of P l ~k o r t i s . ~~ A sponge of the family…”

Phytochemistry and pharmacology of the genus Entandrophragma over the 50 years from 1967 to 2018: a ‘golden’ overview

“…Compound 165 was firstly isolated from a Cameroonian medicinal plant Afzelia bipendensis and later from several fungal sources . Compound 166 , initially reported in 1979 from the marine sponge Plakortis halichondrioides , was also obtained for the first time from plant source in 2015 during investigations of the rare species E. congoënse collected in Cameroon (Figure , Table ).…”