Some aspects of conservative treatment of patients with laryngeal cancer

Abstract

Topicality: According to the National Cancer Registry of Ukraine, the incidence of laryngeal cancer is 4.1%. The treatment of patients with laryngeal cancer depends on the stage of the tumor. The conservative therapy includes both radiation therapy and chemotherapy. Material and methods: The conservative treatment of 93 patients with laryngeal cancer was performed. All patients are divided into two groups according to the localization of cancer: glottis (n=57) and supraglottis (n=36). The course of radiation therapy was conducted in oncology centers. The course of chemotherapy was induction or combined with radiation therapy. The outcome of therapy was evaluated one month after its completion. Tumor response after therapy was assessed by RECIST 1.1. Statistical processing of the obtained results was performed in accordance with the recommendations of Glantz. Results: It was found that metastases to the lymph nodes of the neck were significantly more common in cancer of the supraglottic (χ2=16.074; φ=0.00012; р<0.05). The greater number of recurrences of the tumor of the glottis after conservative therapy (χ2=6.718; φ=0.01345; р<0.05). Three-year recurrence-free survival and overall survival of patients after conservative treatment of laryngeal cancer patients were the same in both groups. Conclusion: The treatment of 93 patients with laryngeal cancer gave an objective tumor response in 96% of patients. The conservative treatment of patients with laryngeal cancer revealed a lower number of tumor recurrences in the supraglottis cancer (20 of 36 patients) compared with the glottis (37 of 57) (χ2= 6.718; φ = 0.01345; p <0.05).

Stopping bleeding from neck injuries in the first stage in military conditions

“…Ушкодження кровоносних судин в області шиї, які супроводжуються масивною кровотечею, трапляється у мирні часи в ЛОР-онкологічній практиці. Це може статися під час складного хірургічного втручання, або спонтанно внаслідок проростання злоякісної пухлини в стінку артерії чи вени [5,10]. Подібні кровотечі внаслідок травми магістральних судин шиї мають місце і під час воєнних дій.…”